苯并硫氮杂卓化合物助催化下甲苯定向氯化  

Ring-chlorination of toluene co-catalyzed by benzothiazepines derivatives

作　　者：黄文涛[1] 屈一新[1] 王水[1] 王际东[1] 

机构地区：[1]北京化工大学化学工程学院,北京100029

出　　处：《工业催化》2010年第1期66-69,共4页Industrial Catalysis

摘　　要：甲苯氯化反应在L酸催化下,加入助催化剂可以调节邻氯甲苯和对氯甲苯比率。合成了三种不同结构杂环苯并硫氮杂卓化合物助催化剂。以SbCl3为催化剂,分别用三种不同结构苯并硫氮杂卓化合物为助催化剂,考察了甲苯定向氯化对氯甲苯选择性的影响;得出最高选择性助催化剂后,找出温度和催化剂用量等工艺条件,使甲苯定向氯化对氯甲苯与邻氯甲苯物质的量之比达到1.29。Ring-chlorination of toluene is usually carried out in the presence of Lewis acids and co-catalysts that can increase the ratio of p-/o- isomers. In this paper, the synthesis of three benzothiazepines derivative compounds are reported. The ring-chlorination of toluene using SbCl3 as a catalyst and benzoth- iazepines derivatives as co-catalysts at different temperature and different dosage of co-catalyst were stuied. All of the compounds can increase the p-/o- ratio in the reaction. Among them N-（2,3-dihydro-1,5- benzothiazepine-4yl）-hydroxylamine exhibited the best co-catalytic results that gave p-/o-ratio of 1.29.

关 键 词：催化化学 助催化剂 苯并硫氮杂卓 甲苯定向氯化 

分 类 号：O643.36[理学—物理化学] TQ426.98[理学—化学]