BMP-4 accelerates PRL secreting,cell proliferation and invasiveness in human prolactinoma  

BMP-4对泌乳素腺瘤细胞分泌、增殖、侵袭性影响的研究(英文)

作　　者：Xiongwei Wang Jian Chen Hui Zeng Bing Long Lei Wang Ping Zhao 

机构地区：[1]The First College of Clinical Medical Science, China Three Gorges University, Yichang 443003, China [2]Department of Neurosurgery, Yichang Center People＇s Hospital, Yichang 443003, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2010年第2期109-112,共4页中德临床肿瘤学杂志（英文版）

摘　　要：Objective： The aim of the study was to explore the bone morphogenetic protein 4 （BMP-4） how to regulate pro- lactin （PRL） secreting, cell proliferation and invasiveness in human prolactinorna. Methods： Ten patients who diagnosed as prolactinoma by clinical characteristics and pathology were divided into two groups, one was sensitive to Brornocriptine, the other was insensitive to Brornocriptine. Every case was conducted by primal cell culture then treated by different concentrations of BMP-4. The cell configuration was observed and PRL hormone was measured in different times. The expressions of BMP-4 rnRNA and BMP-4 in 37 cases of prolactinorna and 8 cases of normal pituitary tissues samples were detected by immunohistochemical and in situ hybridization technique, and the results were analyzed by statistic methods. Results： BMP-4 （5 ng/rnL） could accelerate the secreting of PRL in prolactinorna cell, and it could reach the greatest effect in the concentration of 20 ng/mL. BMP-4 could increase prolactinoma cell proliferation, but when the concentration was 50 ng/rnL, the BMP-4 effect of increasing secreting decreased. When 100 ng/mL, the cell began to die. The effects of the BMP-4 in sensitive group and insensitive group had no difference. The BMP-4 was highly expressed in the prolactinornas and was positively related with the invasiveness grades. Conclusion： BMP-4 have positive regulation in prolactinoma secreting, proliferation, invasiveness effects, BMP-4 probably has the important role in prolactinoma pathogenesis.

关 键 词：PROLACTINOMA bone morphogenetic protein 4 （BMP-4） proliferation prolactin （PRL） 

分 类 号：Q51[生物学—生物化学] Q453