Expression of ABCG2 in human gastric carcinoma  

ABCG2基因在胃癌组织中的表达(英文)

作　　者：NingWang Lin Chen Bo Wei Wei Zheng 

机构地区：[1]Department of General Surgery, General Hospital of Chinese PLA, Beijing 100853, China

出　　处：《The Chinese-German Journal of Clinical Oncology》2010年第3期145-148,共4页中德临床肿瘤学杂志（英文版）

基　　金：Supported by a grant of the National Natural Science Foundation of China (No. 30570522)

摘　　要：Objective:The aim of this study was to investigate the expression of ABCG2 in human gastric carcinoma and its clinical significance.Methods:Expression of ABCG2 was examined with immunohistochemical technique in the specimens from 45 gastric carcinoma tissues and 30 surrounding normal tissues.The mRNA expression of ABCG2 was measured by RT-PCR and real-time quantitative PCR in 30 cases of gastric carcinoma and normal gastric mucosa, respectively.Results:ABCG2 expression was observed in 28 of 45(62.2%) cases by immunohistochemical analysis.In ABCG2-positive tumors, adjacent non-neoplastic tissue was similarly analyzed, revealed that ABCG2 was up-regulated in gastric carcinoma.ABCG2 expression in poorly differentiated/undifferentiated carcinoma was significantly higher than that in well/moderately-differentiated carcinoma(P < 0.05).The mRNA expression of ABCG2 was significantly higher than that in normal gastric mucosa(P < 0.05).Conclusion:ABCG2 plays an important role in the multi-drug resistance of gastric carcinoma.ABCG2 might be an important factor in the research of gastric cancer stem cell.

关 键 词：gastric carcinoma ABCG2 multi-drug resistance side population cancer stem cell 

分 类 号：Q782[生物学—分子生物学] Q421