慢性阻塞性肺疾病患者血清sFas与TNF-α水平的检测和意义  

The detection and Clinical signiflcance of sFas and TNF-α in the serums of patients with chronic obstructive pulmonary disease

作　　者：王迪[1] 姜莉[2] 

机构地区：[1]沈阳市第四人民医院呼吸内科,110031 [2]中国医科大学附属一院呼吸内科

出　　处：《中国实用医药》2010年第4期25-27,共3页China Practical Medicine

摘　　要：目的探讨血清可溶性Fas蛋白(sFas)及肿瘤坏死因子-α(TNF-α)在慢性阻塞性肺疾病(COPD)发病中的作用及临床意义。方法符合COPD诊断标准的急性加重期与稳定期患者各68例,健康对照组20例,采用酶联免疫吸附试验(ELISA)测定血清sFas与TNF-α的水平。结果①COPD急性加重期血清sFas及TNF-α水平与稳定期及对照组比较显著升高(P<0.01);②急性加重期重度COPD血清sFas及TNF-α水平较中度COPD显著升高(P<0.05);③COPD急性加重期血清sFas及TNF-α水平与气流受限指标第一秒用力呼气容积(FEV1)呈负相关(r值分别是-0.256、-0.364,P均<0.05)。结论sFas及TNF-α通过抑制细胞凋亡参与COPD病理损伤,sFas及TNF-α可作为判定COPD严重程度的参考指标。Objective To investigate the function and clinical signiflcance of serum soluble Fas ligand （sFas） and Tumor necrosis factor-a （TNF-α） levels in the patients with COPD.Methods Serum levels of sFas and TNF-α were measured in 68 patients patients during acute episode and after disappearance of symptoms and 20 normal control by enzyme-1inked immunosor-bent assay（ELISA）.Results ①The serum levels of sFas and TNF-α in the patients with AECOPD showed increasing significantly compared with those in patients with stable episode and in normal group（P0.01）;②The serum levels of sFas and TNF-α in the patients with AECOPD showed increasing significantly compared with those in patients with stable episode and in normal group（P0.05）;③The serum levels of sFas and TNF-α in the patients with AECOPD were inversely correlated with Forced expiratory volume in one second （FEV1）（ r=-0.256、-0.364,P0.05）.Conclusions We conclude that increased serum sFas and TNF-α may be associated with progression of COPD though inhibit the cell apoptosis.

关 键 词：慢性阻塞性肺疾病 可溶性Fas分子(sFas) 肿瘤坏死因子-α(TNF-α) 凋亡 

分 类 号：R563.9[医药卫生—呼吸系统] R446.6[医药卫生—内科学]