反射线直角单纯形法优化甘草黄酮阿魏酸乳膏配方  

Optimization of Glycyrrhiza flavonoid and ferulic acid cream by reflect-line orthogonal simplex method

作　　者：刘圣[1,2] 谢军[1,2] 陈象青[1,2] 杨立强[1,2] 苏丹[1,2] 方焱[1,2] 余娜[3] 方卫[4] 

机构地区：[1]安徽医科大学附属省立医院,安徽合肥230001 [2]国家中医药管理局中药制剂实验室(三级),安徽合肥230001 [3]安徽中医学院,安徽合肥230038 [4]皖南医学院,安徽芜湖241002

出　　处：《中国中药杂志》2010年第4期449-452,共4页China Journal of Chinese Materia Medica

摘　　要：目的:优化甘草黄酮阿魏酸乳膏配方,建立乳膏质量控制参数。方法:采用反射线直角单纯形法,考察乳膏伸展性及稳定性,优化乳化剂卖泽52单-硬脂酸甘油酯及透皮促进剂二甲基硅油配方用量。结果:配方中卖泽52单-硬脂酸甘油酯(3∶2)为9.0%,二甲基硅油为2.5%,乳膏稳定,伸展性符合半流体乳膏特性。结论:该乳膏配方合理,质量稳定。反射线直角单纯形法配方试验设计,方法简单、适用,适合乳膏剂配方优化。Objective： To optimize the formula of Glycyrrhiza flavonoid and ferulic acid cream and set up its quality control parameters.Method： Reflect-line orthogonal simplex method was used to optimize the main factors such as amount of Myrj52-glyceryl monostearate and dimethicone,based on the appearance,spreadability and stability of the cream.Result： 9.0%Myrj52-glyceryl monostearate（3∶2）and 2.5% dimethicone were chosen in prescription.The prepared cream presented a good stability after being placed 24 h at 5 ℃,25 ℃ and 37 ℃ respectively,and its spreadability suited with the property of semi-fluid cream.Conclusion： The formula of Glycyrrhiza flavonoid and ferulic acid cream Is suitable,and its quality is stable.The reflect-line orthogonal simplex method is suitable for the formula optimization of cream.

关 键 词：甘草黄酮阿魏酸乳膏 配方优化 伸展性 反射线直角单纯形法 

分 类 号：R283[医药卫生—中药学]