雷公藤及其活性成分药效学和药理学研究的若干进展  

Progress in Tripterygium wilfordiiand its bioactive components in the field of pharmacodynamics and pharmacology

作　　者：水光兴[1] 万毅刚[2] 蒋春明[2] 张慧兰[3] 陈萍[1] 王朝俊[1] 姚建[4] 

机构地区：[1]南京中医药大学中西医结合鼓楼临床学院,江苏南京210008 [2]南京大学医学院附属鼓楼医院,江苏南京210008 [3]南京中医药大学,江苏南京210029 [4]日本山梨大学大学院医学工学总合研究部分子情报伝达学讲座,甲府409-3898

出　　处：《中国中药杂志》2010年第4期515-520,共6页China Journal of Chinese Materia Medica

基　　金：南京市科技计划项目(200905006)

摘　　要：有关雷公藤多苷(multi-glycoside ofTripterygium wilfordii,GTW)临床药效学的研究主要是针对增殖性肾小球肾炎、狼疮性肾炎、类风湿性关节炎、银屑病等免疫相关性疾病。其临床疗效主要表现在改善相应疾病的临床症状,减少蛋白尿和血尿,减轻关节痛和皮肤损害等。GTW及其活性成分雷公藤甲素(triptolide,T4)药理作用包括抗炎、免疫抑制、保护肾组织上皮细胞等,而且,在拮抗器官移植排斥反应、抑制肿瘤生长、拮抗生殖方面也具备有益的作用。In the trials of multi-glycoside of Tripterygium wilfordii（GTW） in the field of pharmacodynamics,some clinical characteristics and symptoms,such as proteinuria,hematuria,joint pain,and skin damage,could be improved in the patients with various diseases including proliferative glomerulonephritis,lupus nephritis,rheumatoid arthritis,psoriasis and other immune-related diseases.In this review,it has been also reported to discuss the effects of GTW and Triptolide（T4）,which is a bioactive component in GTW on anti-inflammatory,immunosuppression,and protection of epithelial cell in kidney.On the other hand,it is possible to have some beneficial effects on organ transplant rejection,tumor growth and anti-fertility.

关 键 词：雷公藤多苷 雷公藤甲素 临床药效 药理机制 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]