变应性疾病患儿皮肤变应原试验与血清尘螨特异性IgE及IgG4水平的关系  

Relationships of Skin Test of Allergens and Serum Dermatophagoides Farina Specific IgE and IgG4 Levels in Children with Allergic Disease

作　　者：谢庆玲[1] 甄宏[1] 胡琼燕[1] 谭颖[1] 温志红[1] 李柳青[1] 梁珍花[1] 

机构地区：[1]广西壮族自治区人民医院儿科,南宁530021

出　　处：《实用儿科临床杂志》2010年第4期240-241,258,共3页Journal of Applied Clinical Pediatrics

基　　金：广西医疗卫生重点科研课题(重200734)

摘　　要：目的探讨变应性疾病(包括支气管哮喘和变应性鼻炎)患儿常见的变应原与血清尘螨特异性IgE(sIgE)和IgG4水平的关系。方法对310例4～13岁变应性疾病儿童进行12种常见变应原皮肤点刺试验,同期采用夹心ELISA方法检测血清尘螨sIgE和IgG4水平。采用SPSS13.0软件进行统计学分析。结果变应性疾病儿童皮肤变应原检测阳性100%(310/310例),≥3种变应原阳性者占35.8%(111/310例)。引起变应性疾病的变应原主要为吸入物,阳性率最高的变应原是粉尘螨。变应性疾病儿童血清尘螨sIgE和IgG4水平明显高于健康对照组(t=14.253、12.314,Pa<0.01)。血清尘螨sIgE水平与皮肤变应原试验阳性种类的多少无相关性(r=-0.004 3,P>0.05);粉尘螨变应原阳性强度与血清尘螨sIgE水平呈正相关(r=0.219 8,P<0.05);血清尘螨sIgE水平与IgG4水平呈一定正相关(r=0.173 0,P<0.05)。结论变应原皮肤点刺试验有助于发现变应性疾病儿童的变应原及了解机体免疫状态强度,提供应尽可能避免接触的变应原,有条件者可进行脱敏治疗。监测血清sIgE和IgG4水平对儿童变应性疾病临床治疗有指导意义。Objective To explore the relationships of the common allergen and the concentration of serum dermatophagoides farina specific IgE（sIgE） and IgG4 in allergic children with asthma and/or allergic rhinitis. Methods Three hundred and ten cases of children with asthma and/or allergic rhinitis were involved in the study, and skin prick tests with 12 common allergens including dermatophagoides were taken in children and the concentrations of serum dermatophagoides farina sIgE and IgG4 were measured with the ELISA method. Results Children with asthma and/or allergic rhinitis all were positive cases for skin test of allergens （310/310 cases）, and 111 cases among 310 cases （35.8%） were positive to ≥3 kinds allergen at the same time. The main allergens which caused allergic diseases in children were inhale con- tents,the highest rate of positive reaction to allergen belonging to dermatophagoides farina. There was significant difference in children with allergic diseases compared with healthy control group increased amounts of serum dermatophagoides farina sIgE and IgG4 （ t = 14. 253,12.314, P, 〈 0.01 ）. The levels of serum dermatophagoides farina slgE had no significant correlation with the kind of positive in skin test in allergic disease children（r = -0. 004 3 ,P 〉0.05） ;and positive intensity in skin test had significant correlation with the concentration of serum dcrmatophagoides farina slgE in patients（ r = 0. 219 8 ,P 〈 0.05 ）, serum dermatophagoides farina slgE had significant correlation with IgG4（ r = 0. 173 0,P 〈 0.05 ）. Conclusions Skinprick test of allergens is helpful to discover allergens and understand immune state in children with allergic disease so as to avoid contacting with them, and also immunotherapy can be better choice for some patients. There exists obvious signi- ficance on detecting the levels of serum dermatophagoides farina slgE and IgG4 for the treatment of children allergic diseases clinically.

关 键 词：哮喘 变应性鼻炎 变应原 皮肤点刺试验 特异性免疫球蛋白E 免疫球蛋白G4 

分 类 号：R725.6[医药卫生—儿科]