人类博卡病毒感染所致细支气管炎的临床特点  

Clinical Characteristics of Bronchiolitis Induced by Human Bocavirus Infection

作　　者：谢淑霞[1] 陆学东[2] 林广裕[1] 庄婉莉[1] 林创兴[1] 周仁彬[1] 周晓华[1] 马廉[1] 

机构地区：[1]汕头大学医学院第二附属医院儿科,广东汕头515041 [2]深圳市第四人民医院检验科,广东深圳518033

出　　处：《实用儿科临床杂志》2010年第4期248-251,共4页Journal of Applied Clinical Pediatrics

摘　　要：目的探讨人类博卡病毒(HBoV)所致细支气管炎的临床特点。方法收集因细支气管炎于2007年6月-2008年5月住院治疗的271例患儿的呼吸道标本(鼻咽分泌物或咽拭子),应用多重PCR技术检测其HBoV,呼吸道合胞病毒(RSV),腺病毒(ADV),鼻病毒(RhV),流感病毒A、B型(FluA、FluB),副流感病毒1、3型(PIV1、PIV3),人类偏肺病毒(hMPV)9种病毒。随机选取RSV感染阳性患儿28例作为对照组。分析HBoV感染组与对照组患儿的临床特点。结果271例标本中,病毒阳性标本163例(60.1%)。其中HBoV阳性21例(12.9%),RSV阳性61例(37.4%);HBoV并其他病毒感染8例(38.1%),与RSV、FluA合并感染各3例,与ADV、RhV合并感染各2例,与hMPV合并感染1例。HBoV感染组与对照组患儿临床资料除在流行季节上有差异外,在性别、发病年龄、临床症状、肺部体征、辅助检查、住院天数、病情严重程度方面比较均无差异。结论HBoV是小儿细支气管炎的另一重要病原体,与RSV感染者在临床表现上无明显差异。HBoV细支气管炎的临床症状较轻,呼吸功能均属于轻中度受损,且以轻度为主,均未出现并发症、重症病例或死亡病例。Objective To explore the clinical characteristics of bronchiolitis induced by human boeavirus （HBoV） infection. Methods Two hundred and seventy - one nasopharyngeal aspirates or nasal swab samples were collected from children with bronchiolitis（ HBoV infection group） from Jul. 2007 to May. 2008. The HBoV ,respirotary syncytial virus（RSV） ,adenovirus （ADV） ,rhiuovirus （RhV） ,influenza virus A, B （ FIuA, FIuB）, parainfluenza virus 1,3 （ PIV1, PIV3 ）, and metapneumovirus （ hMPV ） were detected using the multiplex polymerase chain reaction. Twenty - eight patients with RSV positive samples were randomly selected as control group. The clinical characteristics of bronehiolitis induced by HBoV were analyzed and compared between HBuV infection group and control group. Results Overall at least 1 respiratory virus was detected in 163 cases of 271 samples （60.1%）. Of them,the RSV infection accounted for 61 cases（37.4% ） ;HBoV infection accounted for 21 cases（12.9% ） ;and mixed infection of HBoV and other respiratory viruses accounted for 8 cases（38.1% ） ,among which,3 cases were combined with RSV, 3 cases combined with FluA, 2 eases combined with ADV, 2 cases combined with RhV, and 1 case with hMPV. Between HBoV infection group and control group, excepted the epidemic season, the clinical data showed that no differences were found in gender, age, symptoms, physical signs, radiological findings, hospitalized days and severity of the illness. Conclusions HBoV is an important pathogen of childhood bronchiolitis, and it is diificuh to differentiate HBoV infection from RSV infection just according to the clinical manifestation. The symptoms of bronchiolitis caused by HBoV were mild. The severity was mild or moderate, mostly mild. There was no complications, severe cases or mortality of children with bronehiolitis caused by HBoV.

关 键 词：细支气管炎 人类博卡病毒 呼吸道合胞病毒 

分 类 号：R725.6[医药卫生—儿科]