阿托伐他汀调节急性冠状动脉综合征患者外周血辅助性T细胞亚群失衡的研究  

Atorvastatin modulates T helper 1 cells and T helper 2 cells imbalance in peripheral blood of patients with acute coronary syndrome

作　　者：刘科卫[1] 李晓燕[1] 韩淑芳[1] 许琳[1] 黄志刚[1] 李长春 

机构地区：[1]济南军区总医院心内科 [2]徐州市72433部队干休所

出　　处：《中华老年心脑血管病杂志》2010年第2期120-122,共3页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

摘　　要：目的观察急性冠状动脉综合征(acute coronary,syndromes,ACS)患者应用阿托伐他汀后外周血中1型辅助性T细胞(Th1)和2型辅助性T细胞(Th2)的频率及其相关细胞因子的变化,探讨他汀类药物对ACS患者辅助性T细胞分化的影响。方法选择ACS患者73例,随机分为安慰剂组(36例)和阿托伐他汀组(37例),入选实验后即刻,1、3、14天抽取外周血,检测Th1和Th2频率及其相关细胞因子的浓度,其中Th1相关细胞因子为干扰素γ、白细胞介素2,Th2相关细胞因子为白细胞介素4、白细胞介素10。结果安慰剂组与阿托伐他汀组即刻外周血Th1和Th2频率及其相关细胞因子水平比较,差异无统计学意义(P>0.05);阿托伐他汀组外周血1、3、14天Th1相关细胞因子干扰素γ、白细胞介素2水平较安慰剂组明显降低(P<0.05),而Th2相关细胞因子白细胞介素10水平较安慰剂组明显升高(P<0.05);阿托伐他汀组1、3、14天Th1频率较安慰剂组明显降低(P<0.05),而Th2频率两组间差异无统计学意义(P>0.05)。结论阿托伐他汀通过调节Th1和Th2亚群分化失衡,抑制炎性反应,提示他汀类药物对ACS患者有更广泛的保护作用。Objective To investigate immunomodulation by atorvastatin of T helper 1 and T helper 2（Th1/Th2） subsets imbalance in peripheral blood of patients with acute coronary syndrome （ACS）. Methods Seventy-three patients with ACS were divided randomly into placebo group（36 cases） and atorvastatin group（37 eases）. Th1/Th2 cells frequencies and concentration of related cytokines in peripheral blood were determined before initiation of treatment and on days 1,3 and 14. Results The frequencies of Th1/Th2 cells and concentration of related cytokines had no significant difference between two groups before initiation of treatment （P 〉 0.05）. Th1 related eytokines IFN-γ and IL-2 were in lower levels in atorvastatin group than in placebo group on daysl, 3 and 14 （P 〈 0.05）. Th2 related eytokine IL-10 was in higher level in atorvastatin group than in placebo group （P 〈 0. 05）. The frequency of Thl cells decreased significantly in atorvastatin group compared with placebo group on days 1,3 and 14 （P 〈 0. 05）,while the frequency of Th2 cells had no statistically significant difference between the 2 groups （P 〉 0.05）. Conclusions Atorvastatin significantly attenuated Th1 cells expansion and elevated the concentration of Th2 related cytokines. It can modulate Th1/Th2 development imbalance and inhibit inflammation to protect ACS patients from serious complication.

关 键 词：冠心病 TH1细胞 TH2细胞 T淋巴细胞亚群 降血脂药 

分 类 号：R541.4[医药卫生—心血管疾病]