ApoB/ApoA1比值与代谢综合征的相关性研究  

Association between ApoB/ApoA1 ratio and metabolic syndrome

作　　者：罗蓉[1] 蒋袁娟[2] 成丹[2] 刘洲君[2] 钟立[2] 王邦琼[2] 程庆丰[2] 王永红[1] 李启富[2] 

机构地区：[1]重庆医科大学附属第一医院体检中心,400016 [2]重庆医科大学附属第一医院内分泌科,400016

出　　处：《中国糖尿病杂志》2010年第2期95-97,共3页Chinese Journal of Diabetes

基　　金：重庆市科委科研基金资助项目(2008BB5206)

摘　　要：目的探讨载脂蛋白B(ApoB)/载脂蛋白A1(ApoA1)比值与代谢综合征(MS)及其组分的关系。方法纳入709例重庆地区成年人,测定体重、身高、血压、腰围、空腹血浆葡萄糖(FPG)、空腹血清胰岛素(Fins)及血脂等,计算ApoB/ApoA1、BMI及胰岛素抵抗指数。结果 IR或MS患者,其ApoB/ApoA1比值显著增高;与低ApoB/ApoA1值人群相比,高ApoB/ApoA1值人群发生MS(OR=3.5)和IR(OR=2.3)的风险显著增加(P<0.001)。随MS组分数增加,ApoB/ApoA1比值逐渐增加(P<0.001)。结论 ApoB/ApoA1比值与IR、MS及其组分密切相关,ApoB/ApoA1比值增高是MS发生的重要标志。Objective To assess if the ratio of ApoB/ApoA1 is related to the metabolic syndrome and its components. Methods 709 adults living in Chongqing were enrolled. Weight, height, blood pressure, waist circumferences, fasting plasma glucose（FPG）, fasting serum insulin（Fins）and lipids were measured. ApoB/ApoA1 ratio, BMI and insulin resistance index were calculated. Results ApoB/ ApoA1 ratio was increased in subjects with insulin resistance（IR）and MS. Compared with the low ApoB/ ApoA1 ratio group, the high ApoB/ApoA1 ratio group was more likely to get MS（OR= 3.5）and IR（OR =2. 3）（P〈 0. 001）. Conclusions ApoB/ApoA1 ratio is strongly associated with IR, MS and its components, and a high ApoB/ApoA1 ratio is a valuable marker of MS.

关 键 词：ApoB/ApoA1比值 代谢综合征 胰岛素抵抗 

分 类 号：R589[医药卫生—内分泌]