还原型谷胱甘肽对顺铂肾毒性损伤的保护作用及其机制的研究  

Mechanism of Protective Effect of Reduced Glutathione on Cisplatin-induced Nephrotoxicity

作　　者：顾玉红[1] 杜佳新[2] 张博[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院,哈尔滨市150081 [2]哈尔滨医科大学附属第一临床医学院,哈尔滨市150001

出　　处：《中国医院用药评价与分析》2010年第1期63-65,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察还原型谷胱甘肽对顺铂所致肾毒性损伤的预防性保护作用。方法:100例癌症患者随机分成两组,比较其肾毒性。结果:以顺铂为主的联合化疗有效率均达到53%以上,化疗后对照组肾毒性损伤要高于治疗组。结论:还原型谷胱甘肽能有效地预防顺铂所致肾毒性损伤。OBJECTIVE： To observe the protective effect of reduced glutathione（GSH） against cisplatin-induced nephrotoxicity.METHODS： 100 cancer patients were randomly divided into two groups,with the nephrotoxicity evaluated comparatively.RESULTS： The response rate of combination chemotherapy chiefly cisplation was above 53%, and the nephrotoxicity of control group was more severe than in the treatment group after chemotherapy.CONCLUSION： Reduced glutathione is effective in preventing against cisplantion-induced nephrotoxicity.

关 键 词：还原型谷胱甘肽 顺铂 肾毒性损伤 

分 类 号：R97[医药卫生—药品]