2005～2008年我院抗菌药物使用与细菌耐药性分析  

Analysis of Utilization of Antibiotics and Bacterial Drug Resistance or Our Hospital During 2005～2008

作　　者：何艳春[1] 林伟雄[1] 覃军[1] 

机构地区：[1]南宁市妇幼保健院,南宁市530011

出　　处：《中国医院用药评价与分析》2010年第2期123-125,共3页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:分析抗菌药物使用情况和细菌耐药性的变化趋势,探讨抗菌药物使用频度(DDDs)与细菌耐药性之间的关系,为临床合理应用抗菌药物提供参考依据。方法:统计我院2005～2008年的相关数据资料,分析抗菌药物使用情况和细菌耐药性,分析用药频度与细菌耐药性之间的相关性。结果:头孢菌素类抗菌药物4年来DDDs一直处于第1位,临床用药选择倾向于价格更高、抗菌谱广的2线抗菌药物。DDDs排序前列的药物,耐药率普遍较高。临床分离的细菌以革兰阴性杆菌为主,第3代头孢菌素对铜绿假单胞菌的耐药率应引起临床注意。万古霉素对表葡菌和金葡菌的耐药率最低。氟康唑对白色念珠菌的耐药率多年来居高不下。部分抗菌药物的DDDs与细菌耐药率呈显著正相关关系。结论:应多方并举加强抗菌药物管理,合理使用抗菌药物,减少细菌耐药性的发生,提高临床抗感染治疗的效果。OBJECTIVE：To analyze the utilization of antibiotics and the variation of bacterial drug resistance and discuss the correlation between the DDDs of antibiotics and the bacterial drug resistance so as to provide a reference for clinical rational application of antibiotics. METHODS： The related data from 2005 to 2008 were collected from our hospital for analysis of the utilization of antibiotics and the variation of bacterial drug resistance as well as the correlation between the DDDs of antibiotics and the bacterial drug resistance. RESULTS： The DDDS of cephalosporins dominated the first place over the 4 years. The second line broad spectrum antibiotics with higher price were used preferably in the clinic. The drugs ranked at the leading places on DDDs list were usually with high drug resistance. The bacteria separated were mainly gram-negative bacillus. Great importance should be attached to the resistance of the pseudomonas aeruginosa to the third generation cephalosporin. Staphylococcus epidermidis and staphylococcus aureus showed least resistance to Vancomycin. Candida albicans remained highly resistant to fluconazole over the past four years. There was a marked positive correlation between DDDs of some of the antibacterials and the bacterial drug resistance. CONCLUSION： Hospital should spare no effort to tighten control on antibacterials to promote rational use of antibacteirals,reduce bacterial drug resistance and enhance curative effect of anti-infective therapy.

关 键 词：抗菌药物 耐药性 用药频度 

分 类 号：R978.1[医药卫生—药品]