还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝炎疗效观察  

Therapeutic Efficacy of Reduced Glutathione Combined with Polyene Phosphatidylcholine for Alcoholic Hepatitis

作　　者：莫晨[1] 黄燕苹[1] 陕海丽[1] 吴小娥[1] 刘名[1] 徐铭宝[1] 

机构地区：[1]武警总医院干部病房二科,北京市100039

出　　处：《中国医院用药评价与分析》2010年第2期163-164,共2页Evaluation and Analysis of Drug-use in Hospitals of China

摘　　要：目的:观察还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝炎的临床疗效。方法:60例酒精性肝炎患者均戒酒,随机分为治疗组32例和对照组28例。治疗组给予还原型谷胱甘肽联合多烯磷脂酰胆碱静脉滴注,对照组单独给予多烯磷脂酰胆碱静脉滴注,疗程均为4周。结果:两组患者治疗后临床症状、体征、实验室检查及彩超检查结果均有一定程度的改善,其中治疗组疗效优于对照组,两组疗效比较差异有统计学意义。结论:还原型谷胱甘肽联合多烯磷脂酰胆碱治疗酒精性肝炎疗效满意,无明显不良反应,值得临床推广使用。OBJECTIVE：To evaluate the clinical therapeutic efficacy of reduced glutathione combined with polyene phosphatidylcholine for patients with alcoholic hepatitis. METHODS： A total 60 patients with alcoholic hepatitis who had been abstained from wine were randomly assigned to either trial group （n=32） treated with reduced glutathione plus polyene phosphatidylcholine （iv gtt） for 4 weeks or control group （n=28） treated with polyene phosphatidylcholine alone （iv gtt） for 4 weeks. RESULTS： Clinical symptoms and signs,laboratory examination and B-ultrosound results were all improved in both groups,especially in the trial group and significant differences were noted between the two groups （P0.05）. CONCLUSION： Reduced glutathione combined with polyene phosphatidylcholine is safe and effective for alcoholic hepatitis and hence is worthy of clinical application.

关 键 词：还原型谷胱甘肽 多烯磷脂酰胆碱 酒精性肝炎 酒精性肝病 

分 类 号：R975.5[医药卫生—药品]