Synthesis and Characterization of Ethylenediamine Tetraacetic Acid Tetrasodium Salt Loaded in Microcapsules with Slow Release Properties  

作　　者：谢志章 陈能场 刘承帅 周建民 徐胜光 郑煜基 李芳柏 徐燕玲 

机构地区：[1]Guangzhou Institute of Geochemistry, CAS, Guangzhou 510640, China [2]Guangdong Key Laboratory of Agricultural Environment Pollution Integrated Control, (iuangdong Institute ot Eco-Environment and Soil Science, Guangzhou. 510650, China [3]Graduate School of the Chinese Academy of Sciences, Beijing 100039, China

出　　处：《Chinese Journal of Chemical Engineering》2010年第1期149-155,共7页中国化学工程学报（英文版）

基　　金：Supported by the National Natural Science Foundation of China（30571117）; the Important Sci-Tech Special Project of Guangdong Province China（2006A36703004 2008A030202004）

摘　　要：The microcapsules with cores of ethylenediamine tetraacetic acid tetrasodium salt(Na4-EDTA)and walls of polyurea were synthesized via an interfacial polycondensation reaction with 2,4-tolylene diisocyanate as an oil-soluble monomer and diethyl triamine as a water-soluble monomer.Various manufacturing parameters,including the amount of emulsifier,agitation speed,stirring time and ratios of the wall materials to core materials,were altered to optimize process variables during the synthesis of microcapsules,and the effects of these parameters on the characteristics of the microcapsules were examined.The structure,morphology,mean particle size and size distribution were characterized by optical microscope and scanning electron microscopy(SEM),showing that the mean diameter of optimal microspheres was approximately 6μm,and microcapsules were spherical.In vitro release of Na4-EDTA from these microcapsules was performed in distilled water.Under the optimal preparation conditions, the Na4-EDTA release profiles were biphasic with a burst release followed by a gradual release phase.After an initial burst,a continuous Na4-EDTA release was up to 5-7 days.The optimal synthesis conditions for the microcapsules with stable,good morphology and good controlled-release properties were as follows:emulsifier Span-80 10% (by mass),agitation speed 900 r·min1,stirring time 30 min,and the ratio of the wall materials to core materials 0.15.The microcapsules with cores of ethylenediamine tetraacetic acid tetrasodium salt（Na4-EDTA）and walls of polyurea were synthesized via an interfacial polycondensation reaction with 2,4-tolylene diisocyanate as an oil-soluble monomer and diethyl triamine as a water-soluble monomer.Various manufacturing parameters,including the amount of emulsifier,agitation speed,stirring time and ratios of the wall materials to core materials,were altered to optimize process variables during the synthesis of microcapsules,and the effects of these parameters on the characteristics of the microcapsules were examined.The structure,morphology,mean particle size and size distribution were characterized by optical microscope and scanning electron microscopy（SEM）,showing that the mean diameter of optimal microspheres was approximately 6μm,and microcapsules were spherical.In vitro release of Na4-EDTA from these microcapsules was performed in distilled water.Under the optimal preparation conditions, the Na4-EDTA release profiles were biphasic with a burst release followed by a gradual release phase.After an initial burst,a continuous Na4-EDTA release was up to 5-7 days.The optimal synthesis conditions for the microcapsules with stable,good morphology and good controlled-release properties were as follows：emulsifier Span-80 10% （by mass）,agitation speed 900 r·min1,stirring time 30 min,and the ratio of the wall materials to core materials 0.15.

关 键 词：Na4-EDTA microcapsules interfacial polymerization controlled release 

分 类 号：TQ226.36[化学工程—有机化工] TD971.1[矿业工程—选矿]