环糊精-药物复合纳米粒子的制备及其控制释放研究进展  

Research Advance in Preparation of Nanoparticles Based on Cyclodextrins and Their Applications in Controlled Drug Release Behaviors

作　　者：周应学[1] 范晓东[1] 任杰[1] 田威[1] 

机构地区：[1]西北工业大学理学院应用化学系,西安710129

出　　处：《材料导报》2010年第5期136-140,共5页Materials Reports

基　　金：国家自然科学基金(基金号20674060)

摘　　要：从直接法、小分子键合、星形、树枝状和超支化环糊精大分子胶束及水凝胶、超分子组装7方面论述了环糊精-药物纳米复合体的制备,认为扩散控制、溶胀控制和化学控制是环糊精-药物纳米复合体主要的释放机理。结合释放机理,指出具有超分子结构的复合体系可望成为智能靶向释放领域的主导。The preparation of CDs-drug nanoparticle is summarized from aspects including non-covalent inclusion, covalent conjugate, micelles inclusion of CDs polymer and supramolecular assembly in nano size. Star-shape, dendritic and hyperbranched-CD polymers and CD hydrogel-drug inclusions are described in details. Mechanism of drug controlled release is elucidated in diffusion, target controlled and swelling controlled routes. Combination to drug release mechanisms, CDs-drug complexes integrated supramolecular structure is desired to guide in smart target controlled release.

关 键 词：环糊精 纳米粒子 药控释放 两亲性 包合 

分 类 号：TQ460.4[化学工程—制药化工] O636.12[理学—高分子化学]