GIK加硫酸镁对高血压红细胞内钠镁离子及红细胞膜ATP酶活性的影响  

Effects study of GIK and Mg on Ca^2＋, Mg^2＋ metabolism and adenosine triphosphatase activity in erythrocytes of essential hypertension patients with cerebral infarction

作　　者：袁林 赵萍 

机构地区：[1]市东医院急诊科,上海市200090 [2]贵阳市第二人民医院神经内科

出　　处：《中国心血管病研究》2010年第3期206-207,210,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的研究高血压和高血压脑梗塞患者红细胞内外钠镁改变对红细胞膜ATP酶活性的影响。方法测定20例高血压患者和20例高血压脑梗塞患者红细胞内外钠镁浓度及红细胞膜ATP酶活性，并与20例健康体检者作比较。结果高血压和高血压脑梗塞患者红细胞内存在高钠低镁现象，而红细胞膜Na^＋-K^＋-ATP酶，Ca^2＋Mg^2＋-ATP酶活性均降低。GIK加硫酸镁后高血压脑梗塞患者低镁改变较少，ATP酶活性改变下降。结论GIK加硫酸镁后高血压患者红细胞低镁与红细胞膜受体受损有关。Objective To study the activities of erythrocyte membrane adenosine triphosphatase, Ca^2＋, Mg^2＋ metabolism and the level of ATP in erythrocyte in patients with essential hypertension and cerebral infarction. Methods The study included 20 patients with essential hypertension, 20 patients with cerebral infarction and 20 healthy volunteers. The concentrations of Ca^2＋, Mg^2＋ ,levels of ATP in erythrocytc and activities of Na^＋, K^＋-ATPase, Ca^2＋,Mg^2＋-ATPase in erythrocyte membrane were assayed as previously reported. Results In hypertension group, the activity of No^＋, K^＋-ATPase and Ca^2＋, Mg^2＋-ATPase decreased, and significantly lower concentrations of Mg^2＋ and higher intracellular Ca^2＋ levels in erythrocyte compared with the non-hypertension group （P〈0.05）. ATP concentration in erythrocyte was significant difference in two groups with GIK （P〈0.05）. Conclusions The cellular Ca^2＋ abnormalities may be related to the defective transport mechanisms which may play an important role in the pathogenesis of hypertension. However, intracellular Mg^2＋ level is associated with cellular glucose metabolism.

关 键 词：高血压 GIK 硫酸镁 钠 镁 ATP酶 

分 类 号：R544.1[医药卫生—心血管疾病]