紫锥菊提取物对小鼠骨髓细胞微核影响的试验研究  

Effects of Echinacea Herb P.E on Micronucleus in Mice

作　　者：赵丹[1] 陈秀云[2] 孙雨[1] 汤仁想[1] 刘仁杰[1] 卜仕金[1] 

机构地区：[1]扬州大学兽医学院,扬州225009 [2]扬州大学医学院,扬州225001

出　　处：《中国畜牧兽医》2010年第1期208-210,共3页China Animal Husbandry & Veterinary Medicine

摘　　要：在预试验基础上,选用50只清洁级昆明小鼠随机分为5组,每组10只。紫锥菊提取物经口服灌药的剂量分别为2500、1250、625 mg/kg,另设环磷酰胺阳性对照组与0.9%生理盐水阴性对照组。于第二次给药后24 h处死小鼠,取胸骨脊髓做切片,在油镜下观察微核,计算微核率。试验结果表明,紫锥菊提取物对小鼠骨髓细胞的微核率无影响,结果为阴性。50 Kunming mice were randomly divided into five groups.Echinacea Herb P.E was orally given at a dose of 2.5,1.25 and 0.625 g/kg body weight,respectively.The bone-narrow micronucleus test was undertaken according to the routine method.With a method of two times administration at intervals of 30 h,the mice were killed by cervical dislocation 24 h after oral administration,the permillage of micronucleus cells among polychromatic erythrocytes（PCE） were numbered.The result showed that micronucleus test were not significantly different from the control group,and suggested that Echinacea Herb P.E is no genotoxicity.

关 键 词：紫锥菊提取物 小鼠 微核试验 

分 类 号：S859.8[农业科学—临床兽医学]