血清β2-微球蛋白在HIV／AIDS患者中的临床意义  

Clinical Meaning of β2 Microglobulin in Sera of HIV/AIDS Patients

作　　者：黄菁[1] 王清波[1] 隋俊[1] 虞玲[1] 

机构地区：[1]东南大学附属第二医院南京市第二医院检验科,南京210003

出　　处：《现代检验医学杂志》2010年第1期146-147,150,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨HIV感染者血清β2-微球蛋白的临床意义。方法检测HIV感染者血β2-微球蛋白、CD4^＋T淋巴细胞计数、HIV病毒载量、尿素氮和肌酐，分析其血清β2-微球蛋白浓度变化及与病毒载量、CD4^＋T淋巴细胞计数的相关性以及肾功能的变化。结果HIV感染组血清β2-微球蛋白浓度明显高于正常对照组（P〈0．05），且A，B，C三期逐渐升高（P〈0．05），B，C两期患者明显高于A期（P〈0．05），B期与C期比较差异无统计学显著性意义（P〉0．05）；AIDS组血清β2-微球蛋白浓度显著高于非AIDS组（P〈0．05）；死亡组显著高于未死亡组（P〈0．05）；24例患者接受HARRT治疗三月后血清β2-微球蛋白浓度显著降低（P〈0．05）。HIV感染者血β2-微球蛋白浓度与CD4^＋T淋巴细胞计数呈负相关（r=-0．419，P〈0．01），与病毒载量呈正相关（r=0．571，P〈0．01）。几乎所有的HIV感染者肾功能指标都正常。结论HIV感染者血清β2-微球蛋白升高，可能与免疫系统被激活和淋巴细胞被破坏致机体产生了更多的β2-微球蛋白有关，可反映患者体内病毒复制情况。体内高浓度的β2-微球蛋白可能提示患者预后不佳。血清β2-微球蛋白浓度的检测是进行临床分期、病情预测的重要指标，并可评价HARRT疗效。Objective To investigate the clinical significance of N microglobulin in sera of HIV/AIDS patients. Methods Detected the levels of β2-microglobulin（β2-MG）,Cr,BUN and HIV-RNA vires loads in sera of HIV/AIDS patients,and T lymphocyte subsets count in whole blood and analyzed the correlations between them. Results The level of β2-MG in serum of HIV/AIDS patients was significantly higher than that in healthy group （P〈0.05）. Stadge B and C was significantly higher than that in stadge A,but stadge B was no significance than that in stadge C. Serum β2-MG in AIDS patients was significantly higher than that in none-AIDS patients. Similarly,the death group was significantly higher than that in lively patients. β2-MG in blood was positively correlative with HIV-RNA ,while negatively correlative with CD4 count. And kidney function of almost all patients in this observation were normal. Conclusion The majority of HIV/AIDS patients β2-MG level in blood were elevated and it would be relatively higher with disease progression to AIDS phase. These observations above indicate that the increase of β2-MG in blood may be relative to the destruction of lymphocyte and activation of immune system in HIV/AIDS infection,and is probably due to more β2-MG produced by the individuals,but not the decrease of glomerular filtration rate （GFR） of patients＇ kidney.

关 键 词：Β2-微球蛋白 艾滋病 CD4^+T细胞 病毒载量 

分 类 号：R512.91[医药卫生—内科学] R392.11[医药卫生—临床医学]