环磷酰胺冲击治疗小儿难治性肾病28例疗效观察  

CTX Pulse Therapy for Refractory Nephrotic Syndrome in Children --A Clinical Observation of 28 cases

作　　者：张琴[1] 聂磊[1] 肖玉[1] 钟青[1] 谢集建[1] 

机构地区：[1]郧阳医学院附属太和医院

出　　处：《郧阳医学院学报》1998年第3期140-142,共3页Journal of Yunyang Medical College

摘　　要：目的：观察环磷酰胺冲击治疗小儿难治性肾病疗效。方法：环磷酰胺冲击治疗小儿难治性肾病２８例，每２周１次，每次８～１２ｍｇ／ｋｇ，连用２ｄ。其中频反复及频复发６例，激素耐药２２例，经肾活检８例，其中系膜增殖型肾类４例，膜增殖性肾小球肾炎１例，局灶节段性肾小球硬化１例，膜性肾病１例，增生硬化性肾炎１例。结果：总有效率９６％，完全缓解２４例，部分缓解３例。无效１例，６例频反复频复发病例中，４例获长期缓解，１例复发，１例失访。结论：环磷酰胺冲击治疗小儿难治性肾病疗效显著，缓解率高，副作用相对少。是目前治疗小儿难治性肾病强有力的手段和重大进展。Objective:To evaluate the efficacy of CTX pulse therapy for refractory nephrotic syndrome in children.Methods:The treatment was carried out every two weeks,at a dose of 8-12 mg/kg for two days,in 28 cases, including 6 cases of frequent recurrence,22 cases of hormone resistance 8 cases of renal biopsy which revealed MsPGN in 4,MCN in 1,FSGS in 1,MN in 1 and sclerosis GN in 1.Results:Complete and partial remission occurred in 24 cases and 3 cases respectively,with a total effective rate of 96%.Conclusion:CTX pulse therapy is effective in children refractory nephrotic syndrome.

关 键 词：儿童 肾病 环磷酰胺 冲击治疗 疗效 

分 类 号：R726.92[医药卫生—儿科]