生长因子对骨髓间充质干细胞增殖、分化的影响  

Influence of growth factors on proliferation and differentiation of bone mesenchymal stem cells

作　　者：艾自明[1] 任慧霞[1] 罗俊永[1] 

机构地区：[1]山东大学生化与生物技术药物研究所,济南250012

出　　处：《生命的化学》2010年第1期33-37,共5页Chemistry of Life

摘　　要：骨髓间充质干细胞(bone mesenchymal stemcell,BMSC)是骨髓基质细胞的重要组成部分,由于其不但能与其他细胞一起支持造血干细胞造血,而且还具有较强的增殖功能及多向分化潜能,在一定诱导因素下可定向分化成骨细胞、软骨细胞和脂肪细胞等,近年来已成为生物学和医学的研究热点。本文简要介绍了不同生长因子如血管内皮生长因子、碱性成纤维细胞生长因子、转化生长因子-β等对BMSC增殖、分化的影响。Bone mesenchymal stem cells （BMSCs） is the important part of marrow stromal cells, which can not only support the hemopoiesis with the other cells but also have strong proliferation ability and the multiple differentiation potential of differentiate to osteoblasts, chondrocytes and adipocytes and so on in certain induction factors, and have become a research focus in biology and medicine in recent years. This paper briefly introduces the effects of different growth factors such as vascular endothelial growth factor, basic fibroblast growth factor and transforming growth factor-β on proliferation and differentiation of BMSCs.

关 键 词：骨髓间充质干细胞 生长因子 增殖 分化 

分 类 号：R329[医药卫生—人体解剖和组织胚胎学]