咪达唑仑片在中国朝鲜族和汉族健康人体内的药代动力学  

Pharmacokinetics of midazolam tablets in Chinese Korean and Han healthy volunteers

作　　者：夏东亚[1] 毛桂福[2] 郭涛[1] 杨长青[3] 

机构地区：[1]沈阳军区总医院药剂科,沈阳110840 [2]沈阳药科大学药学院,沈阳110840 [3]延边大学药学院,吉林延吉133002

出　　处：《中国临床药理学杂志》2010年第2期114-117,共4页The Chinese Journal of Clinical Pharmacology

基　　金：全军医学科学技术研究"十一五"计划科技攻关课题基金资助项目(06G023)

摘　　要：目的研究咪达唑仑片(镇静催眠药)在中国朝鲜族和汉族健康人体内的药代动力学。方法9名朝鲜族和10名汉族健康受试者,单剂量口服咪达唑仑片15mg,用高效液相色谱法测定血浆中咪达唑仑的浓度,用DASVer2.0.1软件计算药代动力学参数。结果咪达唑仑片在朝鲜族和汉族健康受试者的主要药代动力学参数:tmax分别为(0.63±0.72),(1.52±0.74)h,Cmax分别为(189.03±82.05),(103.11±26.37)μg.L-1,t1/2(3.82±2.33),(2.96±0.77)h,AUC0-12(369.75±85.47),(368.95±103.63)μg.h.L-1,AUC0-∞(403.29±124.28),(397.29±124.06)μg.h.L-1。结论朝鲜族和汉族健康受试者单剂量口服咪达唑仑片后的药代动力学参数存在较大的个体差异,平均血药浓度-时间曲线存在双峰现象,2组间tmax、Cmax的差异有统计学意义(P<0.05)。Objective To investigate and compare the pharmacokinetics of midazolam in Chinese Korean and Han healthy volunteers after oral administration. Methods Nine healthy Chinese Korean volunteers and ten healthy Han volunteers were given 15 mg midazolam tablets. The concentration of midazolam in plasma was determined by HPLC method and the pharmacokinetic parameters were calculated by DAS 2.0. 1 software. Results The pharmaeokinetie parameters of midazolam in Chinese Korean and Han were as follow ： tmax were （0.63±0. 72） and （ 1.52± 0.74） h, C were （ 189.03 ± 82.05 ） and （ 103.11 ± 26.37） μg·L^-1 t1/2 were （3.82±2.33） and （2.96 ±0.77） h, AUC0_1：were （369.75 ±85.47） and （368.95 ±103.63） μg·h·L^-1 , AUC0-12 were （403.29 ± 124. 28） and （397.29 ± 124.06）μg·h·L^-1 , respectively. Conclusion There is large interindividual variabilities in pharmacokinetic parameters of Chinese Korean and Han healthy volunteers, after administration. There were double peaks in plasma concentration-time profile after oral administration. There is significant difference in the t and Cmaxbetween Chinese Korean and Han healthy volunteers.

关 键 词：咪达唑仑 药代动力学 高效液相色谱法 朝鲜族人 汉族人 

分 类 号：R969[医药卫生—药理学] R978.5[医药卫生—药学]