大黄素固体脂质纳米粒的制备及理化性质研究  

Preparation and Physico-chemical Property of Emodin Solid Lipid Nanoparticles

作　　者：张洪[1] 成蓓[2] 

机构地区：[1]武汉大学人民医院药学部,武汉430060 [2]武汉大学药学院

出　　处：《中国药师》2010年第3期326-329,共4页China Pharmacist

摘　　要：目的:制备大黄素固体脂质纳米粒,并对其理化性质进行研究。方法:用乳化-溶剂挥发法制得大黄素素固体脂质纳米粒,并对其粒径、形态、表面电位、包封率、体外释药性质等进行研究。采用全体液平衡反向透析法研究体外释药性质。结果:所制固体脂质纳米粒外观形态圆整,粒度分布均匀,平均粒径为253 nm,电位为-25.4 mV,包封率为(56.31±2.06)%。药物体外释放符合Weibull线性方程。结论:固体脂质纳米粒可作为大黄素新型缓释给药系统。Objective： To prepare emodin solid lipid nanopartieles （EMO-SLN） and study the physical and chemical properties. Method： EMO-SLN was prepared by the emulsification-evaporation and its particle size, morphology, Zeta potentials, entrapment efficiency and drug release behaviors in vitro were investigated. The bulk-equilibirum reverse dialysis bag technique was employed to study drug release behaviors in vitro. Result： The mean particle size was 253 nm with a narrow particles distribution of polydispersity index. The Zeta potential of the optimized emodin-loaded solid lipid nanoparticles was - 25.4 mV, and the drug entrapment efficiency was （56. 31 ± 2.06） %. Drug release behavior in vitro correspond the Weibull linear equation. Conclusion： Solid lipid nanopartieles were the appropriate drug delivery system for the slow-release of Emodin.

关 键 词：大黄素 固体脂质纳米粒 乳化蒸发-低温固化法 全体液平衡反向透析法 

分 类 号：R944.9[医药卫生—药剂学] R945[医药卫生—药学]