增氧与被动吸烟对新西兰兔血气指标的影响  

Effect of Environment Oxygen Supplement and Passive Smoking on Blood Gas Indexes in Rabbits

作　　者：张成梅[1] 于学慧[1] 武传涛[1] 宋文延[2] 尹志圣[1] 刘兆平[1] 

机构地区：[1]山东大学实验动物中心,山东济南250012 [2]山东大学医学院诊断学研究所,山东济南250012

出　　处：《环境与健康杂志》2010年第1期28-30,共3页Journal of Environment and Health

摘　　要：目的研究增加氧气浓度及被动吸烟对家兔血气指标的影响。方法将80只成年健康普通级新西兰家兔随机分为供氧吸烟组、单纯供氧组、被动吸烟组、对照组,每组20只,雌雄各10只。供氧环境为安放两台雾化供氧机(每台雾化供氧机增氧量为600～1000ml/min,氧纯度为99.5%,雾化气中负离子浓度10000～16500个/cm3),被动吸烟环境为点燃人用卷烟,任其自燃,每次25支,4h/次,进行24h。测定家兔的五项血气指标(氧分压、二氧化碳分压、氧含量、氧饱和度、血液pH值),并进行2×2析因方差分析。结果增加氧气浓度使家兔血液氧分压明显升高(P<0.01),二氧化碳分压明显降低(P<0.01),氧含量和氧饱和度有增加的趋势,对血液pH值影响不明显(P>0.05);被动吸烟对血气五项指标的影响均不明显(P>0.05);增氧与被动吸烟两因素之间无明显交互作用(P>0.05)。结论增加氧气浓度有改善机体氧代谢的作用;被动吸烟对五项血气指标影响不显著。Objective To study the influence of environment oxygen supplement and passive smoking on the blood gas indexes in rabbits. Methods Eighty adult Newzealand white rabbits were randomly divided into 4 groups,20 in each .The oxygen supplement and passive smoking group was exposed to cigarette smoke produced by 25 burning cigarettes ,four hours per time, consecutively for twenty-four hours,simultaneously exposed to oxygen produced by two oxygen generators （600-1 000 ml/min per generator）. The oxygen supplement group was exposed to oxygen produced by two oxygen generators （600-1 000 ml/min per generator） consecutively for twenty-four hours.The passive smoking group was exposed to cigarette smoke produced by 25 burning cigarettes ,four huors per time, consecutively for twenty-four hours.The control group was exposed to general feeding environment. The analysis of variance of factorial design （2 ×2） was conducted, five blood gas indexes were measured. Results Under the condition of surroundings oxygen increasing, the partial pressure of blood oxygen was improved significantly （P〈0.01）, the partial pressure carbon dioxide decreased significantly （P〈0.01）,oxygen content and saturation appeared an improved tendency,and no obvious impact on blood pH value was observed. Under the condition of passive smoking, all the five blood gas indexes variations were not significant （P〉0.05）. No evident interaction was found between surroundings oxygen increasing and passive smoking. Conclusion Oxygen metabolism can be improved by environment oxygen supplement in rabbits, and the effect of passive smoking on the investigated five blood gas indexes is not considered significant.

关 键 词：被动吸烟 增氧 氧分压 二氧化碳分压 氧饱和度 

分 类 号：R994.6[医药卫生—毒理学]