铝作用于cAMP-蛋白激酶A途径及对学习记忆的影响  

Effects of Aluminum on cAMP/Protein Kinase A Approach Related to Learning and Memory

作　　者：孙家郡[1] 邢伟[1] 

机构地区：[1]中国医科大学基础医学院生物化学与分子生物学教研室,辽宁沈阳110004

出　　处：《环境与健康杂志》2010年第2期177-179,共3页Journal of Environment and Health

基　　金：2008年辽宁省高等学校科研项目(2008848)

摘　　要：铝是一种常见的金属元素,其神经毒性可能是影响学习记忆机制的因素之一。突触传递长时程增强(LTP)是研究学习记忆的一个可用电生理模型,cAMP蛋白激酶A(PKA)途径是神经元重要的信号传导通路,在学习记忆形成过程中起重要的作用。铝可以影响学习记忆机制中某些环节(如神经递质、钙离子浓度、蛋白激酶等),导致智力及认知能力的下降。该文根据近年来国内外在该领域的研究进展,从电生理学、生物化学等方面阐述了铝对学习记忆机制的影响及与cAMP/PKA途径的关系。Aluminum is a common metal element, and its nervous toxicity probably has an effect on the learning and memory mechanism. Long-term potentiation （LTP） is an available electrophysiology-model, cAMP/protein kinase A （PKA） approach is an important signal transduction pathway of nerve cells, and plays an important role in the process of learning and memory mechanism. Aluminum has some adverse effects on learning and memory through influencing some links, such as neurotransmitter,Ca^2＋ concentration,protein kinase and so on. According to the recent studies in this field, in electrophysiology and biochemistry, the present paper reviewed the effects of aluminum on the learning and memory mechanism, as well as the role of cAMP/PKA approach.

关 键 词：铝 环状腺苷酸(cAMP) 蛋白激酶A(PKA) 学习记忆 

分 类 号：R994.6[医药卫生—毒理学]