银杏酸和槟榔碱二元微乳剂的研制  

Study on Binary Micro-emulsion of Ginkgolic Acids and Arecoline

作　　者：刘萌[1] 杨小明[1] 何广立[2] 丁艳[1] 

机构地区：[1]江苏大学化学化工学院,江苏镇江212013 [2]江苏省镇江市疾病预防控制中心,江苏镇江212013

出　　处：《安徽农业科学》2010年第5期2446-2448,共3页Journal of Anhui Agricultural Sciences

基　　金：江苏省社会发展基金项目(BS2005042);镇江市社会发展基金项目(SH2008056)

摘　　要：[目的]制备银杏酸和槟榔碱二元微乳剂。[方法]采用滴定法绘制伪三元相图,考察表面活性剂、助表面活性剂和油相对微乳区的影响。[结果]当DBS-Ca和农乳600#的质量比Km=1∶1时,DBS-Ca-农乳600#-乙酸乙酯-水体系形成的微乳区面积最大,对药物的容量也最大;当表面活性剂和助表面活性剂的总质量与乙酸乙酯的质量比(AS/O)=3∶2时,制得的二元微乳剂最稳定。[结论]该微乳体系制得的银杏酸和槟榔碱二元微乳剂符合要求。[Objective] The aim was to prepare binary micro-emulsion of ginkgolic acids and arecoline.[Method] By using titration method to prepare the pseudoternary phase diagram,the effects of surfactants,co-surfactants,oils on micro-emulsion regions were examined.[Result] The results showed that the area of the micro-emulsion was the largest when the Km value was 1∶1 in the system of DBS-Ca/phenylethyl phenol polyoxyethylene ether/ethyl acetate/water,which had the maximum capacity of drugs.When the value of AS/O equaled 3∶2,the binary micro-emulsion had the best stability.[Conclusion] The binary micro-emulsion of ginkgolic acids and arecoline obtained by this system suffices the quality standard of micro-emulsion.

关 键 词：银杏酸 槟榔碱 伪三元相图 二元微乳剂 

分 类 号：S482[农业科学—农药学]