低分子肝素非注射制剂的研究进展  

Advances in research on non-injecting preparations of low molecular weight heparin

作　　者：李攀[1] 秦永文[1] 

机构地区：[1]第二军医大学长海医院心血管内科,上海200433

出　　处：《药学服务与研究》2010年第1期13-17,共5页Pharmaceutical Care and Research

摘　　要：低分子肝素(LMWH)是临床广泛应用的抗凝药物,常用的注射剂型存在的一些缺陷影响了临床治疗血管栓塞性疾病的疗效。为了克服这些不足,近年来很多学者开始研究LMWH的其他给药途径,包括口服制剂、舌下给药、直肠栓剂、鼻腔给药,以及经肺、经皮肤给药。LMWH非注射制剂有助于提高患者的用药依从性和减少药物不良反应。本文就LMWH非注射制剂的优缺点等方面作一综述,从而介绍更多LMWH给药途径,以供特定患者人群选择。Low molecular weight heparin（LMWH） is a kind of anticoagulant which has been extensively used for the treatment of embolism in clinic.It is mainly administered by injection,which has several limitations influencing efficacy in treatment of thrombosis.In order to solve these problems,a lot of researches have been made for various non-injecting medicating methods including oral,sublingual,rectal,nasal,pulmonary and transdermal administration routes.Non-injecting preparations of LMWH can enhance patients＇ compliance and minimize adverse drug reactions.This review focuses on non-injecting preparations of LMWH and analyses their advantages and shortages for the purpose of introducing alternative medicating methods for special patients.

关 键 词：肝素 低分子 给药 口服 给药 非注射 综述 

分 类 号：R973.2[医药卫生—药品]