三氟化硼及其硅胶负载物催化下酮类的Baeyer-Villiger氧化反应  

Catalytic Baeyer-Villiger oxidation of ketones with boron trifluoride and its silica supported

作　　者：杨志旺[1] 陈琴[1] 马国富[1] 何海龙[1] 雷自强[1] 

机构地区：[1]西北师范大学化学化工学院生态环境相关高分子材料教育部重点实验室,甘肃兰州730070

出　　处：《西北师范大学学报（自然科学版）》2010年第2期73-77,共5页Journal of Northwest Normal University(Natural Science)

基　　金：国家自然科学基金资助项目(20774074);甘肃省自然科学基金资助项目(3ZS061-A25-018);西北师范大学科技创新基金资助项目(NWNU-KJCXGC-03-56)

摘　　要：考察了三氟化硼及其硅胶负载催化下30%H2O2对酮类的Baeyer-Villiger氧化反应.结果表明,两种催化剂都能在温和条件下催化酮类氧化得到相应的酯和内酯;小分子三氟化硼对2-金刚烷酮、环戊酮、2-甲基环己酮的催化氧化基本实现完全转化,产物内酯的选择性分别达到99%,99%和74%,其对链状的4-甲基-2-戊酮的氧化表现出较好的催化性能,相同条件下底物转化率和产物酯的选择性分别可达25%和99%;硅胶负载三氟化硼催化酮类Baeyer-Villiger氧化反应时,产物内酯的选择性很好,催化剂制备过程简单,并具有较好的重复使用性能.Boron trifluoride etherate（BFs. OEt2）and silica supported BF3 are used as catalysts for Baeyer- Villiger oxidation of ketones with 30% hydrogen peroxide as oxidant. Many ketones are effectively oxidized to the corresponding esters or lactones under mild reaction conditions. 2-andamantanone, cyclopentanone, 2-rnethyl-cyclohexanone are efficiently oxidized to the corresponding lactones by boron trifluoride etherate（BFa ~ OEtz） with the product selectivity of 99%, 99% and 74%, respectively. The catalyst also shows catalytic acticity for the oxidation of 4-methyl-2-heptanone with the substrate conversion, as well as ester selectivity of 25% and 99%, respectively. The silica supported BFa affords high lactone＇s selectivity in Baeyer-Villiger oxidation of many ketones. It can be easily prepared and recycled in the oxidations.

关 键 词：三氟化硼 硅胶负载三氟化硼 酮 催化 Baeyer-Villiger氧化反应 

分 类 号：O621.254.1[理学—有机化学]