“江山”牌卷烟对小鼠免疫功能、SOD及LPO的影响  

Effects of "Jiangshan" cigarette smoke on immune function,SOD,and LPO in mice

作　　者：李钢成 孟庆乃[1] 冯笑梅[1] 张小利[1] 王世祥[2] 王锐[3] 袁慧 骆凯[2] 郑晓晖[2] 

机构地区：[1]上海烟草(集团)公司天津卷烟厂,天津雪莲路13号300163 [2]西北大学生命科学学院,西安太白北路229号710069 [3]西安交通大学第一附属医院,西安健康路1号710061 [4]陕西省烟草专卖局质检站,西安雁南四路19号710014

出　　处：《中国烟草学报》2010年第1期85-88,共4页Acta Tabacaria Sinica

基　　金：国家烟草专卖局资助项目(No.212199911001)

摘　　要：研究了"江山"牌卷烟对小鼠免疫功能、及对小鼠肝脏组织过氧化脂质(LPO)含量和超过氧化物酶(SOD)活性的影响。通过给小鼠染毒,观察"江山"牌卷烟对小鼠网状内皮系统吞噬廓清能力、对二硝基氟苯(DNFB)所致迟发型超敏反应、血清溶血素抗体的影响,采用硫代巴比妥酸比色法和黄嘌呤氧化酶法测定小鼠肝脏组织中LPO含量和SOD活性。结果表明"江山"牌卷烟可明显拮抗对照卷烟对小鼠DNFB诱导迟发型超敏反应的抑制作用,提高小鼠溶血素水平,小鼠肝组织中SOD的活性明显升高,LPO含量明显降低。与对照卷烟比较,"江山"牌卷烟可能具有提高小鼠免疫功能的作用。Effects of ＂Jiangshan＂ cigarette smoke on immune function and activity of lipid peroxidation （LPO） and superoxide dismutase （SOD） of liver in mice were studied. The ability of reticulendothelial system, the delayed type hypersensitivity （DTH） induced by 2,4-dinitrofluorobenzene, and the antibody of serum hemolysin were observed. The levels of LPO and SOD were determined by methods of thiobarbituric acid （TBA） and xanthine oxidase respectively. Results showed that the suppression on DTH and antibody of serum hemolysin of control cigarette could be antagonized by ＂Jiangshan＂ cigarette smoke obviously, and the level of LPO of liver was reduced and the level of SOD was increased markedly. Compared with control cigarette, ＂Jiangshan＂ cigarette can enhance the specific immune function of mice.

关 键 词：“江山”牌卷烟 免疫功能 

分 类 号：R114[医药卫生—卫生毒理学]