水相中硼酸催化的α-氨基腈的合成  

Synthesis of α-Aminonitriles Catalyzed by Boric Acid in Water

作　　者：吕东旭[1] 白银娟[1] 杨添[1] 孙伟[1] 史真[1] 

机构地区：[1]合成与天然功能分子化学教育部重点实验室西北大学化学与材料科学学院,西安710069

出　　处：《化学通报》2010年第2期184-187,共4页Chemistry

基　　金：国家自然科学基金项目(20472067);陕西省教育厅专项基金项目(09JK734)资助

摘　　要：报道了以水为溶剂,硼酸为催化剂,室温下通过三组分Strecker反应合成α-氨基腈类化合物的方法,考察了不同溶剂及催化剂对反应的影响。与经典的Streaker反应相比,它具有产率高、反应时间短和环境友好等优点。目标化合物的结构经1HNMR、IR确证。A method for the three-component Strecker reaction with water as solvent, boric acid as catalyst at room temperature is reported. The effects of different solvents and catalyst on the reaction were studied. Compared to the classical Streaker reaction conditions, the present method has the advantages of good yields, short reaction time and environmentally friendly. The structures of the products were characterized by ^1H NMR and IR spectra.

关 键 词：α氨基腈 硼酸一锅法 水相反应 

分 类 号：TQ226.61[化学工程—有机化工]