非典型性脑膜瘤11例临床病理分析  

ATYPICAL MENINGIOMA: A CLINICOPATHOLOGIC REVIEW OF 11 CASES

作　　者：王学丽[1] 陈青[1] 郝青[1] 王学军[1] 

机构地区：[1]滨州市中心医院病理科,山东滨州251700

出　　处：《齐鲁医学杂志》2010年第2期163-164,共2页Medical Journal of Qilu

摘　　要：目的探讨非典型性脑膜瘤(AM)的病理学特点与临床复发率。方法回顾性分析11例AM病人的临床资料与光镜下的组织学特征,计数核分裂象、细胞异型程度以及肿瘤坏死的情况,并随访病人的生存情况和复发率。结果AM光镜下瘤细胞密度增大,核浆比例增高,核仁明显,多伴有奇异核细胞出现和微小坏死灶。11例AM病人中,3例复发,1例复发后转变为间变性脑膜瘤,再次手术后1年死亡。结论AM是一种界于良性与恶性之间的交界性肿瘤,有较高的复发率和较强的临床侵袭行为。Objective To investigate the pathologic characteristics and clinical recurrence rate of atypical meningioma （AM）. Methods A retrospective analysis was done in 11 cases of AM in terms of their clinical data and histological characteristics, such as cell caryomitosis, cell heterotype and tumor necrosis. The survival and recurrence were followed up. Results Microscopically, AM was characterized by hypercellularity, high karyoplasma ratio, prominent macronucleoli, strange heterokaryocyte and tiny focal necrosis. Of 11 cases, recurrence was noted in three, and one transformed into anaplastic meningioma and died 1 year after reoperation. Conclusion AM is a borderline tumor between benign and malignant with a high recurrence and stronger aggressive clinical behavior.

关 键 词：脑膜瘤 非典型性 病理学 临床 诊断 鉴别 

分 类 号：R651.1[医药卫生—外科学]