新生儿缺氧缺血性脑病血清IL-18和钙离子的动态变化及意义  

The changes and significances of IL-18 and Ca^(2+) in neonatal hypoxic ischemic encephalopathy

作　　者：柏金秀[1] 杨小巍[1] 姬静璐[1] 王欣[1] 湛要五[1] 贾浩[1] 

机构地区：[1]河北大学附属医院儿科,河北省保定市071000

出　　处：《河北医药》2010年第4期394-395,共2页Hebei Medical Journal

摘　　要：目的通过监测新生儿缺氧缺血性脑病(HIE)患儿血清白介素-18(IL-18)和钙离子(Ca2+)的水平变化,探讨IL-18、Ca2+与HIE的相互关系及临床意义。方法HIE新生儿为HIE组,对照组为正常新生儿。2组分别于生后第1、3、7、14天测定血清IL-18和Ca2+,分析IL-18、Ca2+的变化及意义。结果HIE患儿生后第1、3、7天血清IL-18含量较对照组均有升高,Ca2+含量较对照组均有降低(P<0.01);且中、重度HIE患儿血清IL-18含量高于轻度HIE患儿,Ca2+含量低于轻度HIE患儿(P<0.01)。第14天HIE组的IL-18、Ca2+含量与对照组比较差异无统计学意义(P>0.05)。结论IL-18、Ca2+参与HIE的整个发病过程,检测血清中IL-18、Ca2+水平对判断HIE脑损伤的程度、病情发展及预后具有临床意义。Objective To observe the changes of levels of IL-18 and Ca^2＋ in neonatal hypoxic-ischemic encephalopathy（HIE） ,and to investigate the correlation among IL-18, Ca^2＋ and HIE. Methods 60 HIE patients were randomly classified. 10 normal neonates were enroILed as control group. In each group, the concentrations of IL-18 and Ca^2＋ on 1 day,3 days,7 days and 14 days after birth. The the changes and significances of IL-18 and Ca^2＋ were observed and analyszed. Results The levels of serum IL-18 in HIE groups on the first day after birth were significantly higher than those of the control group, however, the levels of Ca^2＋ were significantly lower（ P 〈 0. 01 ）. The levels of IL-18 in patients with moderate and severe HIE were significantly higher than those of patients with mild HIE, while the levels of Ca^2＋ were obviously lower（ P 〈 0.01 ）. There was no significant difference in the serum levels of IL-18 and Ca^2＋ on the 14 days after birth between HIE groups and control group（ P 〉0.05）, Conclusion IL-18 and Ca^2＋ are involved in the course of HIE. The levels of IL-18 and Ca^2＋ in HIE patients are positively correlated with the severity, condition and prognosis of HIE.

关 键 词：婴儿 新生 缺氧缺血性脑病 白介素-18 钙离子 

分 类 号：R722.1[医药卫生—儿科]