91例儿童人苍白杆菌败血症病原菌及耐药性分析  

Identification and Antimicrobial Susceptibilities of Ninety-one Children with Sepsis Caused by Ochrobactrum Anthropi

作　　者：刘健龙[1] 张洁[1] 聂波丽[1] 李先斌[1] 周舟[1] 刘建良[1] 

机构地区：[1]湖南省儿童医院,湖南长沙410007

出　　处：《实用预防医学》2010年第3期447-448,共2页Practical Preventive Medicine

基　　金：湖南省科技厅资助课题(2008FJ3193)

摘　　要：目的探讨儿童人苍白杆菌败血症的病原学及耐药性特点,为临床的正确诊疗提供依据。方法对从2008年1-11月湖南省儿童医院收治儿童败血症患者中分离的病原体用VITEK2compact进行鉴定和药敏试验,同时对患者临床资料进行分析。结果8264份血标本检出需氧菌876株,检出率10.60%;其中革兰阴性(G-)杆菌542株,检出率61.87%,人苍白杆菌有91株,占革兰阴性(G-)杆菌的16.79%。人苍白杆菌以1～4岁儿童感染率较高。人苍白杆菌对青霉素类和第一、二、三代头孢菌素耐药,对头孢吡肟敏感率高,对亚胺培南、环丙沙星100%敏感。结论人苍白杆菌可引起儿童败血症,耐药率高。头孢吡肟、亚胺培南是人苍白杆菌感染的首选用药。Objective To study the etiology and drug resistance characteristics of children with sepsis caused by Ochrobactrum anthropi,and to provide the clinical evidence for the correct treatment. Methods Ninety-one strains of Ochrobactrum anthropi were collected from children with sepsis due to Ochrobactrum anthropi in Hunan Children＇s Hospital from January to November in 2008. All of them were identified with VITEK2compact,drug susceptibility tests were interpreted according to the Clinical and Laboratory Standard Institute （CLSI,2007）,and the patients＇ clinical data were collected to conduct statistical analysis. Results Among 8,264 blood samples,876 strains of aerobic bacteria were detected,with the detection rate of 10.60%; of which 542 strains were gram-negative （G-）bacteria,with the detection rate of 61.87%,91 strains were Ochrobactrum anthropi,accounting for 16.79% of gram-negative （G-） bacteria. 1-to 4-year-old children had a higher infection rate of Ochrobactrum anthropi. Ochrobactrum anthropi was resistant to penicillin and the first-,second-and third-generation cephalosporins,but sensitive to cefepime,imipenem,and ciprofloxacin. Conclusions Ochrobactrum anthropi can cause sepsis in children,and with a higher rate of drug resistance. Cefepime and imipenem are the first choice of medicines for Ochrobactrum anthropi infection.

关 键 词：儿童 败血症 人苍白杆菌 耐药 

分 类 号：R915[医药卫生—微生物与生化药学]