5-氟尿嘧啶-1-基乙酸合成新方法  

A Novel Synthetic Method for 5-fluorouracil-1-yl Acetic Acid

作　　者：常军[1] 李成吾[1] 富海涛[2] 王佳霁[1] 

机构地区：[1]沈阳理工大学材料科学与工程学院,辽宁沈阳110168 [2]沈阳产品质量监督检验研究院,辽宁沈阳10022

出　　处：《广州化工》2010年第3期68-69,共2页GuangZhou Chemical Industry

摘　　要：5-氟尿嘧啶与氢氧化钾作用得到5-氟尿嘧啶单钾盐,5-氟尿嘧啶单钾盐与氯乙酰乙酯得到N1-乙酸乙酯取代5-氟尿嘧啶,再经酸性条件下水解合成了5-氟尿嘧啶-1-基乙酸,产率85%,产品纯度99.52%,并采用红外、核磁、紫外的方法表征了产物的结构,确定了产品的最佳反应条件。采用此法制备5-氟尿嘧啶-1-基乙酸原料便宜易得,操作方法简单,产物具有较高的产率和纯度。5 - fluorouracil potassium salt was synthesized by the reaction of 5 - fluorouracil and potassium hydroxy, and 5 - fluorouracil potassium salt reacted with ethyl chloroaceticate, then hydrolyze in HC1, obtained 5 - fluorouracil - 1 -yl with the yield of 85% and 99.52% purity（by HPLC）. FT- IR, 1H -NMR and UV were used to characterize the structure of the product, and the optimum reaction condition was confirmed. This synthetic method had the merits such as cheapness of materials, simplification of manipulation, and high in both yield and purity.

关 键 词：5-氟尿嘧啶 衍生物 5-氟尿嘧啶-1-基乙酸 抗肿瘤药物 

分 类 号：TQ463.54[化学工程—制药化工]