羧酸和酯类化合物在Friedel-Crafts反应中的应用  

Application of Carboxylic Acids and Esters to Friedel-Crafts Reactions

作　　者：毛建新[1] 王存进[1] 罗云[1] 章珺[1] 郑小明[1] 

机构地区：[1]浙江大学催化研究所浙江省应用化学重点实验室,浙江杭州310028

出　　处：《石油化工》2010年第3期233-240,共8页Petrochemical Technology

基　　金：国家自然科学基金项目(20573094)

摘　　要：就固体酸催化剂对羧酸和酯类化合物的活化作用、相关的Friedel-Crafts反应催化体系和反应机理方面的研究进展进行了综述。其中,羧酸类化合物主要涉及饱和脂肪酸、芳基脂肪酸和烯酸;酯类化合物主要涉及直链酯和环状酯,重点是γ-丁内酯和丙二酸环亚异丙酯及其衍生物。特别是以烯酸、内酯或丙二酸环亚异丙酯为反应物,通过一步Friedel-Crafts反应可得到茚酮或萘酮类化合物,具有较高的应用价值,但是其工艺过程需要进一步的绿色化。开发新型催化剂及研究催化剂酸中心对反应物的活化机理是Friedel-Crafts反应绿色化的发展方向。The research proceedings on application of carboxylic acids and esters in Friedel-Crafts reaction were reviewed, particularly for the activations of carboxylic acids and esters over solid acid catalysts, the effective catalyst system and the reaction mechanism. The carboxylic acids can be saturated, unsaturated or aromatic substituted alkanoic acid. The esters are straight-chain or cyclic ones, the latter mainly refer to y-butyrolactone, Meldrum＇ s acid and their derivatives. Especially, the compounds of indanone or tetralone can be obtained by using y-butyrolactone, unsaturated carboxylic acid and Meldrum＇ s acid as reactants in one-step by Friedel-Crafts reaction. These processes have high application value, but require further green. The further research to make Friedel-Crafls reactions green should be focused on developing new catalysts and studying the activation mechanism of reactants on the catalytic acid sites.

关 键 词：羧酸 酯 内酯 茚酮 萘酮 Friedel—Crafts反应 固体酸催化剂 

分 类 号：TQ244.2[化学工程—有机化工]