COX-2和MMP-7在大肠癌组织中的表达及意义  

Clinical Significance of Expression of Cyclooxygenase-2 and Matrix Metalloproteinase-7 in Human Colorectal Carcinoma

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作  者:李霞[1] 朱清静[1] 蔡艳萍[1] 周星[1] 朱尤庆[2] 罗峻[3] 

机构地区:[1]武汉市医疗救治中心 [2]武汉大学中南医院消化内科 [3]武汉大学中南医院病理科,湖北武汉430023

出  处:《中外医疗》2010年第8期35-37,共3页China & Foreign Medical Treatment

摘  要:目的研究环氧合酶-2(cyclooxygenase-2;COX-2)蛋白和基质金属蛋白酶-7(matrix metalloproteinase-7;MMP-7)蛋白在人大肠癌组织中的表达及意义。方法应用免疫组化法检测40例大肠癌及其癌旁正常组织中COX-2及MMP-7蛋白表达水平。结果大肠癌组织中COX-2蛋白表达阳性率87.5%(35/40),明显高于癌旁正常组织25%(10/40)(P<0.01);大肠癌组织MMP-7蛋白表达阳性率85%(34/40),明显高于癌旁正常组织35%(14/40)(P<0.01);COX-2阳性表达组中MMP-7阳性率为91.4%(32/35),COX-2阴性表达组中MMP-7阳性率为40%(2/5),二者差异具有统计学意义(P<0.05)。结论COX-2蛋白可能通过促进MMP-7的表达从而共同促进了大肠癌的生长及转移。Objective To study the expression of cyclooxygenase--2(COX--2)protein and matrix metalloproteinase-7(MMP--7)protein in human colorectal carcinoma and evaluate the relationships between the two proteins.Methods Expression of COX-2 and MMP- 7 protein was examined in 40 colorectal carcinoma and adjacent normal tissues by immunohistochemical technique. Results The positive rate of COX-2 protein was significantly higher in colorectal carcinoma(87.5%)than in normal tissues(25%,P〈0.01).The positive rate of MMP--7 protein was significantly higher in colorectal carcinoma(85%)than in normal tissues(35%,P〈0.01)and it was correlated with the expression of COX--2 protein(P〈0.05).Conclusion It is suggested that high expression of COX--2 protein may play an important role in the progression and metastasis of colorectal carcinoma through up--regulating the expression of MMP--7 protein.

关 键 词:大肠癌 环氧合酶-2 基质金属蛋白酶-7 

分 类 号:R753.34[医药卫生—皮肤病学与性病学]

 

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