条件性位置偏爱形成对小鼠吗啡行为敏化的影响  

Effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice

作　　者：孙婷[1] 邹赢锌[2] 郑杰民[2] 黄矛[2] 张晓冬[2] 

机构地区：[1]海军总医院药剂科,北京100048 [2]第二军医大学基础部新药评价中心,上海200433

出　　处：《药学实践杂志》2010年第1期23-24,72,共3页Journal of Pharmaceutical Practice

摘　　要：目的研究条件性位置偏爱对小鼠吗啡行为敏化的影响。方法应用计算机视频分析系统观察吗啡和氟哌啶醇对雄性小鼠单位时间内的总活动度的影响。同时观察条件性位置偏爱形成后,小鼠单位时间内的总活动度、平均速度和穿梭次数的改变。结果吗啡给药后显著增加小鼠单位时间内的总活动度,氟哌啶醇使小鼠总活动度减少,并且对抗吗啡引起的总活动度的增加。条件性位置偏爱形成后,吗啡组小鼠在白箱停留的时间显著增加,但总活动度、平均速度和穿梭次数与训练前相比显著减少。结论氟哌啶醇可抑制吗啡诱导的行为敏化,条件性位置偏爱形成后可能引起多巴胺系统功能降低。Objective To observe the effect of development of conditioned place preference on behavioral sensitization induced by morphine in mice. Methods Male mice were used as subjects. Total range of motion after treated with morphine and haloperidol were evaluated by locomotion activity video analysis system. Total range of motion, average velocity and number of shuttle were also evaluated after the psychical dependence established. Results Distance travelled was significantly increased after administration of morphine. Distance travelled was significantly decreased in haloperidol group. Haloperidol could intercept hyperlocomotion induced by morphine. After treated with morphine, time to the morphine side significantly increased. Distance travelled, average velocity and number of shuttle also decreased significantly. Conclusion Haloperidol could suppress behavioral sensitization induced by morphine. The dopamine system functions may be inhibited after conditioned place preference established.

关 键 词：吗啡 条件性位置偏爱 行为敏化 

分 类 号：R965[医药卫生—药理学]