白细胞介素6受体基因多态性与肥胖的关联研究  

Association of interleukin-6 receptor genepolymorphism with obesity

作　　者：闫彩凤[1] 向红丁[1] 陈伟[1] 平凡[1] 杨敏[1] 

机构地区：[1]中国协和医科大学,北京协和医院内分泌科,北京100730

出　　处：《中华内分泌代谢杂志》2010年第2期125-126,共2页Chinese Journal of Endocrinology and Metabolism

基　　金：基金项目：首都医学发展科研基金资助（2002-1017）

摘　　要：探讨白细胞介素6受体（IL-6R）基因多态性与肥胖间的相关性，观察到IL-6R基因多态性与体重指数、腰围明显相关，Asp／Asp纯合子发生肥胖的危险性较Ala／／Ala纯合子更高（OR=1．32，95％CI1．07～1．68，P=0．041）。提示白细胞介素6受体基因变异在肥胖的发病中具有一定的作用。To examine the relationship between genetic variants in the interleukin-6 receptor gene and obesity. The result showed that the carriers of Asp358 homozygotes had higher risk in developing obesity when compared with Ala358 homozygotes （ OR = 1.32,95% CI 1.07-1.68, P = 0. 041 ）. Interleukin-6 receptor gene polymorphism was significantly associated with obesity.

关 键 词：白细胞介素6受体基因 多态性 单核苷酸 腰围 体重指数 

分 类 号：R589.2[医药卫生—内分泌]