蛋白亚硝基化研究进展及其在植物抗病中的作用  

Progress in Research Techniques of Protein S-nitrosylation and Its Role in Plant Disease Resistance

作　　者：陈晨[1] 沈昕[1] 储成才[2] 王义琴[2] 

机构地区：[1]北京林业大学生物科学与技术学院,北京100083 [2]中国科学院遗传与发育生物学研究所,北京100101

出　　处：《中国生物工程杂志》2010年第2期127-133,共7页China Biotechnology

基　　金：国家自然科学基金资助项目(30600407)

摘　　要：蛋白亚硝基化(S-nitrosylation)是一种在一氧化氮作用下与蛋白半胱氨酸巯基共价结合,使巯基-SH转化为-SNO的反应。作为一种氧化还原依赖的翻译后调控形式,蛋白亚硝基化对多种蛋白的功能具有调节作用,越来越多的证据表明蛋白亚硝基化在植物抗病中发挥重要的作用。简要介绍了蛋白巯基亚硝基化的特点、检测方法、功能研究以及在植物抗病调节方面的最新进展。S-nitrosylation,the covalent attachment of an Nitric oxide（NO） moiety to Cys residues of proteins,resulting in the formation of S-nitrosothiols（SNO）,is a prevalent posttranslational protein modification involved in redox-based cellular signaling.S-nitrosylation has been shown to regulate the function of many proteins which are involved in a wide array of cellular activities.The growing body of evidence now suggested that S-nitrosylation may also have a centrol function in plant disease resistance.The basic concepts of S-nitrosylation,the detection methods,functional studies and the recent progress of S-nitrosylation in plant disease resistance were summarized.

关 键 词：蛋白亚硝基化 去亚硝基化 一氧化氮 植物抗病 

分 类 号：Q819[生物学—生物工程]