硝酸纤维素手性固定相的制备及其在手性化合物拆分中的应用  

Preparation of Nitrate Cellulose Stationary Phase and Its Application in Separation of Chiral Compounds

作　　者：江运东[1] 张美[1] 谢生明[2] 宋卿[3] 袁黎明[1] 

机构地区：[1]云南师范大学化学化工学院,云南昆明650092 [2]华东师范大学化学系,上海200062 [3]云南省疾病预防控制中心,云南昆明650022

出　　处：《化学研究》2010年第2期77-79,共3页Chemical Research

基　　金：云南省自然科学基金重点项目(2005E0006Z)

摘　　要：将硝酸纤维素涂敷于硅烷化的硅胶表面,制备了一种新型的纤维素衍生物类涂渍型高效液相色谱手性固定相;采用湿法装柱,在正相色谱条件下将其用于手性化合物分离,取得了较好的分离效果.Nitrate cellulose was coated on silylated silica gel to prepare a novel coating-type stationary phase of high-performance liquid chromatography （HPLC）. The resulting stationary phase was packed into an HPLC column of 250 min× 4.6 mm and used for the separation of chiral compounds under a pressure of 40 MPa. It was found that the coated stationary phase could be well used to separate chiral compounds with a satisfactory efficiency.

关 键 词：硝酸纤维素 高效液相色谱 手性固定相 制备 手性拆分 应用 

分 类 号：O657.7[理学—分析化学]