谷参肠安对溃疡性结肠炎患者细胞因子的影响  

Effect of Compound Glutamine Entero-soluble Capsule on the cytokines in patients with ulcerative colitis

作　　者：魏思忱[1] 郑国启[1] 孔郁[1] 田树英[1] 张秀刚[1] 宋慧[1] 

机构地区：[1]沧州市中心医院消化内科,河北沧州061001

出　　处：《中成药》2010年第3期366-369,共4页Chinese Traditional Patent Medicine

基　　金：河北省科技攻关计划项目(052761917)

摘　　要：目的:探讨谷参肠安胶囊(L-谷氨酰胺、甘草、茯苓和白术)治疗活动期溃疡性结肠炎(UC)的疗效及对细胞因子的影响。方法:活动期UC患者82例,随机分为两组,对照组(39例)口服柳氮磺胺吡啶(或美沙拉嗪),同时用琥珀酸氢化考的松及庆大霉素、蒙脱石散保留灌肠,治疗组(43例)在上述治疗基础上,口服谷参肠安胶囊。治疗2个月后评价两组疗效以及患者血中细胞因子IL-10和IL-18的变化。结果:治疗后两组临床表现总评分明显下降,且治疗组优于对照组,两组比较差异有统计学意义(P<0.05)。两组治疗后结肠镜表现均有改善,治疗组优于对照组;疾病活动指数(DAI)降低(P<0.05),降低幅度治疗组优于对照组(P<0.05)。两组均未见明显的不良反应。治疗后细胞因子IL-10的水平升高,且治疗组优于对照组,而IL-18虽有降低,但两组间无统计学差异。结论:谷参肠安口服辅助治疗活动期UC近期疗效明显。AIM：To observe the therapeutic effect of Compound Glutamine Entero-soluble Capsule（CGC）（L-glutamin,Radix et Rhezoma glycyrrhizae,Poria and Rhizoma atractylodis macrocephalae） on active ulcerative colitis（UC） and to investigate its influence on the cytokines.METHODS：Eighty-two patients with active UC were randomly assigned to the treatment group（43 patients）and the control group（39 patients）.Patients in two groups received the basic treatment with salicylazosulfapyridine or mesalazine by month and retention enema（hydrcortisone sodium succinate,Gentamicin,and Smectite Powder）,the patients in treatment group with the addition of CGC.The efficacy,such as the clinical symptom score,colon mucosa inflammation and the changes of IL-10 and IL-18 in serum 2 months after treatment were evaluated.RESULTS：Two months after treatment,the clinical symptom score and colon mucosa inflammation decreased significantly,especially in the treatment group（P〈0.05）.The decrease of disease active index in the treatment group was superior to those in the control group（P〈0.05）.The average serum level of IL-10 significantly increased,especially in the treatment group（P〈0.05）.The average serum level of IL-18 was low,but no statistic difference in two groups.No adverse reaction was found in all patients.CONCLUSION：Compound Glutamine Entero-soluble Capsule shows supportive treatment effect on active ulcerative colitis.

关 键 词：谷参肠安胶囊 溃疡性结肠炎 IL-10 IL-18 

分 类 号：R287[医药卫生—中药学]