缺氧诱导因子-1α及内皮型一氧化氮合酶的研究进展  

The Advancement of Hypoxia-inducible Factor-1α and Endothelial Nitric Oxide Synthase

作　　者：李革[1] 任甫[1] 

机构地区：[1]辽宁医学院,辽宁锦州121001

出　　处：《辽宁医学院学报》2010年第1期85-88,共4页Journal of Liaoning Medical University (LNMU) Bimonthly

基　　金：国家自然基金资助项目:编号:30971529

摘　　要：在探讨高原群体缺氧耐受机制时,许多与缺氧耐受相关的功能基因的研究迅速发展起来,缺氧诱导因子-1α(HIF-1α)及内皮型一氧化氮合酶(NOS3)是其中的两个重要基因。目前一些研究表明在高原缺氧适应中这些基因发挥着重要的作用。本文对HIF-1α和NOS3的研究进展进行综述,旨在初步探讨其与高原缺氧适应及其它疾病的相关性,为以后进行前瞻性研究提供基础资料。Many research about the functional genes related to hypoxia tolerance have developed rapidly with the study of the mechanism of high altitude hypoxic tolerance. For example, hypoxia-inducible factor-let （HIF-1α） and endothelial nitric oxide synthase （NOS3） are the two major genes. At present, some studies have shown that these genes play an important role in high altitude adaptation. In this paper, we reviewed the research progress of HIF-1 α and NOS3 to investigate the relationship between the high altitude adaptation and some diseases, and provide the basic information for future prospective studies.

关 键 词：缺氧诱导因子-1Α 内皮型一氧化氮合酶 进展 

分 类 号：R555[医药卫生—血液循环系统疾病]