SLE患者血清氧化LDL水平检测分析  

Analysis of oxidized LDL levels in sera of patients with systemic lupus erythematosus

作　　者：王成[1,2] 杨翠华[1,2] 张春妮[2] 汪俊军[2] 史蓓蕾[2] 刘小传[2] 李克[2] 

机构地区：[1]南京师范大学生命科学学院江苏省分子医学生物技术重点实验室,南京210046 [2]南京军区南京总医院检验科,南京210002

出　　处：《临床检验杂志》2010年第2期116-118,共3页Chinese Journal of Clinical Laboratory Science

基　　金：国家自然科学基金资助项目(批准号:NSFC30872411;NSFC30950100)

摘　　要：目的检测、分析SLE患者血清氧化低密度脂蛋白(ox-LDL)水平。方法采用ELISA检测47例SLE患者和42例健康对照者血清ox-LDL,同时对受检者常规血脂水平进行测定。结果SLE患者ox-LDL水平显著高于对照组[(143.40±65.36)mg/L vs(65.77±26.19)mg/L,P<0.01],总胆固醇、三酰甘油、LDL-胆固醇(LDL-C)和载脂蛋白B(apo B)等常规血脂水平也明显升高。以对照组ox-LDL水平的x-+s值为cut off值,SLE组37例高于此值(敏感性78.7%),健康对照组6例异常(特异性85.7%)。多因素分析显示,患者组ox-LDL水平与LDL-C显著正相关。结论SLE患者血清ox-LDL水平升高,检测ox-LDL水平有助于预测SLE患者As的发生风险。Objective To measure and analyze serum oxidized low density lipoprotein （ox-LDL） concentration in systemic lupus erythematosus （SLE） patients. Methods The concentrations of ox-LDL were studied in 47 SLE patients and 42 healthy controls with an ELISA assay and serum lipoproteins levels were also determined. Results Serum ox-LDL levels were significantly elevated in SLE patients compared with those in controls [ （143.40 ± 65.36） mg/L vs （65.77± 26.19） rag/L, P 〈 0.01 ]. The concentrations of total cholesterol, triacyglycerols, LDL-cholesterol （LDL-C）, and apolipoprotein B were also markedly higher in SLE than in controls. Thirty seven patients （ sensitivity of 78% ） were found to have elevated ox-LDL concentrations, whereas only 6 of 42 controls （ specifici- ty of 86% ） had high ox-LDL levels. When multiple linear regression analysis was performed, LDL-C concentration was found to be the only variable showing a significant correlation with ox-LDL level in SLE group. Conclusions ox-LDL levels are significantly elevated in SLE patients, which is an important risk factor for predicting atherosclerosis in the patients.

关 键 词：低密度脂蛋白 氧化修饰 血脂 系统性红斑狼疮 动脉粥样硬化 危险因素 

分 类 号：R446.1[医药卫生—诊断学]