莫诺苷及其代谢物在大鼠体内的尿排泄动力学  

Urinary Pharmacokinetics of Morroniside and Its Metabolite in Rats

作　　者：李小娜[1,2] 孙志明[3] 郭炜[1] 李敏[3] 张兰桐[1] 

机构地区：[1]河北医科大学药学院药物分析教研室,河北石家庄050017 [2]华北煤炭医学院药学系 [3]华北煤炭医学院附属医院,河北唐山063000

出　　处：《中国医药工业杂志》2010年第3期197-199,共3页Chinese Journal of Pharmaceuticals

摘　　要：考察莫诺苷及其代谢物在大鼠体内的尿排泄动力学规律。大鼠按20mg/kg灌胃给予莫诺苷水溶液后于不同时间采集尿样,用HPLC法分析尿中莫诺苷及其代谢物的经时变化。尿液排泄药动学试验表明,莫诺苷的尿排泄t1/2为1.69h,24h内莫诺苷及其代谢物经尿排泄完全,莫诺苷的排泄量主要集中在0～3h,约占总排泄量的68.5%,代谢物的排泄量在6～9h达高峰,约占总排泄量的66.5%。莫诺苷经尿液排泄的总量不足给药量的1.4%。The urinary pharmacokinetics of morroniside and its metabolite were investigated in rats. Morroniside solution was administered orally at a dose of 20 mg/kg, and then urine was collected. Concentrations of morroniside and its metabolite in urine were determined by HPLC. Morroniside and its metabolite in urine were completely excreted in 24 h. The excretion t1/2 of morroniside was 1.69 h. Main excretive amount of morroniside was 68.5 % in 0 - 3 h and the amount of its metabolite was 66.5 % in 6 - 9 h. The recovery of morroniside in urine was lower than 1.4 %.

关 键 词：莫诺苷 山茱萸 代谢物 尿排泄动力学 高效液相色谱 

分 类 号：R969[医药卫生—药理学]