盐酸甲氯芬酯的曙红Y褪色分光光度法测定  

Fading Spectrophotometric Method for Determination of Meclofenoxate Hydrochloride with Eosin Y

作　　者：马卫兴[1,2] 刘英红[1] 沙鸥[1] 周岩[1] 

机构地区：[1]淮海工学院化学工程学院 [2]江苏省海洋资源开发研究院,江苏连云港222005

出　　处：《中国医药工业杂志》2010年第3期213-215,共3页Chinese Journal of Pharmaceuticals

基　　金：江苏省高校自然科学研究计划资助项目(No.05KJB150003)

摘　　要：利用盐酸甲氯芬酯与曙红Y在Clark-Lubs缓冲液(pH3.6)中相互作用而使体系褪色,建立了一种快速测定制剂中盐酸甲氯芬酯含量的新方法。该体系的最大褪色波长在506nm处,表观摩尔吸光系数为1.059×104L·mol-1·cm-1,盐酸甲氯芬酯在2～18μg/ml浓度范围内符合比耳定律。A fast fading spectrophotometric method was established for the determination of meclofenoxate hydrochloride based on the reaction of meclofenoxate hydrochloride with eosin Y in the Clark-Lubs buffer media （pH 3.6）. The apparent molar absorptivity of complex was 1.059× 10^4 L.mol^-1.cm^-1 at 506 nm. Beer＇s law was obeyed in the range of 2 - 18 μg/ml for meclofenoxate hydrochloride.

关 键 词：盐酸甲氯芬酯 曙红Y 褪色反应 分光光度法 测定 

分 类 号：TQ460.72[医药卫生—药物分析学] O657.32[化学工程—制药化工]