乙肝疫苗母婴阻断无(弱)应答影响因素的非条件Logistic回归分析  

NON-CONDITION LOGISTIC ANALYSIS ON INFLUENCING FACTORS OF HEPATITIS B VACCINE IN PREVENTING MOTHER-TO-INFANT TRANSMISSION OF HEPATITIS B VIRUS

作　　者：张文增 史继新 冀国强 马玉欣 张松建 

机构地区：[1]北京顺义区疾病预防控制中心,北京101300

出　　处：《现代预防医学》2010年第6期1023-1025,共3页Modern Preventive Medicine

摘　　要：[目的]探讨乙肝疫苗母婴阻断无（弱）应答发生的影响因素。[方法]选择北京市顺义区2005-2008年孕期或住院分娩时乙肝病毒表面抗原（HBsAg）检测阳性母亲所生的儿童,分析乙肝疫苗母婴阻断无（弱）应答发生的影响因素,在单因素的基础上进行多因素非条件Logistic回归分析,探索接种乙肝疫苗阻断HBV母婴传播的影响因素。[结果]共调查223名儿童,抗-HBs阳性者185人,阳性率为85.7%,无（弱）应答率为14.3%。非条件Logistic回归分析结果显示,HepB首针及时接种、儿童完成接种年龄、分娩方式及母亲HBV感染状况是影响儿童抗-HBs无弱应答率的主要因素,其发生无（弱）应答的OR值分别为0.264、2.292、2.158和0.370。[结论]乙肝疫苗接种后的无（弱）应答率与文献报道基本一致。HepB首针未及时接种、儿童完成接种年龄较大、顺产及母亲双阳性的儿童乙肝疫苗母婴阻断时容易发生无（弱）应答。[Objective] To explore the influencing factors of Hepatitis B vaccine （HepB） in preventing mother-to-infant transmission of Hepatitis B virus （HBV）. [Methods] The children whose mothers were HBsAg positive during pregnancy or childbearing were selected in Shunyi District of Beijing between 1997 and 2005, the non （low）-responsive rate after HepB immunization was calculated and the influencing factors were determined with simple factor analysis and multi-factors Logistic regression model. [Results] 223 children were investigated, from whom 185 were positive in HBsAb and the positive rate was 85.7%. The rate of non （low） -responsiveness was 14.3%. The result of non-condition Logistic regression analysis showed that timely vaccination of the first HBV vaccine incubation, and the age of completing incubation, delivery mode and mother’s HBV infecting status were the important influencing factors of HepB in preventing mother-to-infant transmission of HBV, and the value of OR were 0.264, 2.292, 2.158 and 0.370, respectively. [Conclusion] The results were according to literature, not timely vaccination of the first HepB needle, the older completing incubaltion age of HBV vaccine, eutocia and mother with both positive HBsAg and HBeAg were the important influencing factors on the non （low）-responsiveness rate of HepB in preventing mother-to-infant transmission of HBV.

关 键 词：乙肝疫苗 无(弱)应答 影响因素 儿童 

分 类 号：R512.62[医药卫生—内科学]