ITP患者骨髓巨核细胞和血小板参数的临床分析  

CLINICAL ANALYSIS OF BONE MARROW MEGAKARYOCYTE AND PLATELET PARAMETER WITH IDIOPATHIC THROMBOCYTOPENIC PURPURA

作　　者：刘艳奎[1] 朴美花[1] 金春岩[1] 崔海霞[1] 崔海 金京子 

机构地区：[1]吉林省延吉市延边大学医院检验科,延吉133000 [2]延边妇婴医院 [3]延吉市二院

出　　处：《现代预防医学》2010年第6期1195-1196,共2页Modern Preventive Medicine

摘　　要：[目的]探讨特发性血小板减少性紫癜(ITP)患者骨髓巨核细胞和血小板4项参数的变化及临床意义。[方法]分析经我院确治的99例ITP患者骨髓巨核细胞和血小板数(Plt)、血小板平均体积(MPV)、血小板平均分布宽度(PDW)、大血小板比率(P-LCR)的关系及比较治疗前后血小板4项参数变化。[结果]①骨髓巨核细胞数和Plt没有相关性,但颗粒型、产板型巨核细胞和Plt有一定相关性(P﹤0.01)。②Plt与MPV呈负相关(P﹤0.01);MPV与PDW、P-LCR,PDW与P-LCR呈正相关(P﹤0.05)。③ITP患者治疗前Plt明显低于对照组,而MPV、PDW、P-LCR明显高于对照组,差异有统计学意义(P﹤0.001);治疗后Plt上升MPV、PDW、P-LCR下降与治疗前比较差异有统计学意义(P﹤0.001)。[结论]观察血小板参数对骨髓巨核细胞产血小板功能及病情判断、疗效观察有重要意义。[Objective] To study the clinical significance of bone marrow megalokaryocyte and four parameters of platelet changes in idiopathic thrombocytopenic purpura （ITP）. [Methods] The platelet total （PLT）, mean platelet volume （MPV）, platelet distribution width （PDW）, platelet larger cell ratio （P-LCR） and bone marrow megalokaryocyte were detected in 99 cases of ITP before and after treatment. [Results] （1） There was no correlation between bone marrow megakaryocyte and platelet, but the granular type and the platelet-producing megakaryocyte were correlated with platelet （P﹤0.01）. （2） PLT was negatively with MPV （P﹤0.01）; MPV was positively correlated with PDW and P-LCR; PDW was positively correlated with P- LCR （P﹤0.05）. （3） PLT in ITP before the treatment was significantly decreased than that in the control group （P﹤0.001）. The PLT was significantly increased after the treatment, MPV, PDW and P-LCR were significantly reduced （ P ﹤ 0.001）. [ Conclusion] Observation of the PLT parameter has important significance for platelet-producing function of bone marrow megakaryocyte, telling the degrees of the states of the patients and observing the effectiveness of therapy of ITP.

关 键 词：特发性血小板减少性紫癜 血小板参数 巨核细胞 

分 类 号：R551.3[医药卫生—血液循环系统疾病]