婴幼儿对乙肝疫苗低应答和无应答对策的研究  

Study on Strategy with Low-and Non-Response to HBV Vaccine in Infants

作　　者：龚晓红 邢玉兰 刘立荣 康沛[1,2,3,4,5,6,7] 徐凤美 张瑞琴 敦哲[1,2,3,4,5,6,7] 郑全良 张震[1,2,3,4,5,6,7] 李立琴 

机构地区：[1]北京市卫生防疫站 [2]北京市佑安医院 [3]北京市崇文区卫生防疫站 [4]北京市海淀区卫生防疫站 [5]北京市昌平县卫生防疫站 [6]北京市西城区卫生防疫站 [7]北京市密云县卫生防疫站

出　　处：《疾病监测》1998年第12期447-450,共4页Disease Surveillance

摘　　要：本文对１０１名低、无应答儿童采用不同方案加强免疫，进行随机对照前瞻性研究观察，表明，对母亲ＨＢｓＡｇ阳性的低、无应答婴幼儿采用注射分枝杆菌多糖与乙肝疫苗（３０μｇ×３）联合应用，免后１年抗体阳转率可达９０％左右；对母亲ＨＢｓＡｇ阴性的低、无应答婴幼儿采用加强１支１０μｇ乙肝疫苗，可使近一半婴幼儿产生抗－ＨＢｓ。利用ＰＣＲ检测低、无应答者的ＨＢＶ－ＤＮＡ，仅有３８５％为ＨＢＶ感染者，母亲为ＨＢｓＡｇ阳性者的无应答婴幼儿若不进行加强免疫，仍存在着ＨＢＶ感染的危险性。In order to explore the best boaster strategy for children with low-and non-response to HBV vaccine, a randomized controlled trial for evaluation of simple HBV vaccine (30μg×3) and HBV vaccine (30μg×3) combined with Mycobacteria Phlei Polysaccharides (MPS, MPS-A 20μg/ml×15, MPS-B 2μg/ml×15) was conducted in 59 infants of HBsAg positive mothers. The infants with low-and non-response were tested for HBV-DNA using PCR, only 3.8% were infected with HBV, most of the infants were free of HBV infecion. Therefore, the booster vaccination with the HB vaccine and MPS was necessary, especially for children of HBsAg positive mothers.

关 键 词：低应答 无应答 乙肝疫苗 分枝杆菌多糖 婴幼儿 

分 类 号：R512.620.1[医药卫生—内科学]