中国汉族人群脂蛋白脂酶Pvu Ⅱ基因多态性与冠心病关系的Meta-分析  

Meta-analysis on correlation between polymorphism of LPL Pvu Ⅱ and coronary heart disease in Chinese Han population

作　　者：周丽婷[1] 史杰萍[2] 叶琳[1] 崔建林[3] 王春华[1] 隋春生[1] 刘特[4] 梁楠[4] 

机构地区：[1]吉林大学公共卫生学院劳动卫生与环境卫生学教研室,吉林长春130021 [2]吉林大学公共卫生学院流行病与卫生统计学教研室,吉林长春130021 [3]南开大学医学院生理学教研室,天津300071 [4]吉林大学公共卫生学院,预防医学专业吉林长春130021

出　　处：《吉林大学学报（医学版）》2010年第2期405-407,共3页Journal of Jilin University：Medicine Edition

基　　金：吉林省科技厅科研基金资助课题(200505138)

摘　　要：目的:评价中国汉族人群中脂蛋白脂酶(LPL)Pvu Ⅱ基因多态性P-P-基因型与冠心病的关系,阐明LPL基因在冠心病发生发展中的作用。方法:按照系统评价的要求全面检索PubMed、Medline医学数据库、中国期刊全文数据库、万方数据库、维普信息数据库等数据库,共搜集中国汉族人群LPLPvu Ⅱ基因多态性与冠心病关系的8个病例-对照研究。评价纳入文献的质量,采用RevMan5.0软件,对符合纳入标准的文献进行Meta-分析。结果:共纳入6篇文献,累计病例593例,对照572例。LPLPvu ⅡP-P-基因型个体发生冠心病危险性的OR值为2.32,OR值95%可信区间为(1.64～3.28,P<0.05)。合并结果漏斗图基本对称,纳入的文献不存在发表偏倚,具有较好的代表性。结论:中国汉族人群中LPLPvu ⅡP-P-基因型携带者易于发生冠心病,提示LPL基因可能为中国汉族人群冠心病的遗传易感基因。Objective To evaluate the relationship between the polymorphism of lipoprotein lipase（LPL） PvuⅡP-P-genetype and coronary heart disease（CHD） in Chinese Han population,and expound the function of LPL PvuⅡP-P-genetype in occurrence and development of CHD.Methods According to the requirements of Cochrane systematic review,a thorough literature search about studies on the relationship between the polymorphism of LPL PvuⅡ and CHD was performed among PubMed,Medline,Chinese periodical full text database,Wanfang datebase and Vip information database.The qualities of documents were evaluated.RevMan 5.0 software was used to perform the Meta-analysis on those valid studies.Results Six literatures met the inclusion criteria,including 593 patients and 572 controls.The distribution of LPL PvuⅡgenotype of both groups in every study was in accordance with Hardy-Weinberg equilibrium.No heterogeneity was found between the six studies,nor the statistical publication bias.With the M-H mathematical model,the pooled odds ratio for PvuⅡP-P-/（P-P＋/P＋P＋） in CHD group against control group was 2.32,95%CI（1.64,3.28）,P0.05.The funnel plots was symmetrical,which means there was no publish bias between the six studies.Conclusion Chinese Han population who carries the LPL P-P-genotype has a higher risk to be subjects of CHD,which suggests that the LPL P-P-genotype may be the susceptibility gene of CHD.

关 键 词：冠心病/遗传学 脂蛋白脂酶 META-分析 

分 类 号：R541.4[医药卫生—心血管疾病]