地尔硫对心绞痛患者血清内源性洋地黄物质的影响  

Influence of diltiazem on serum endogenous digitalislike substance in patients with angina pectoris

作　　者：曹雪滨[1,2] 王士雯[1,2] 韩丽 龙秀琴 沐贤友[1,2] 陈德玲 李启芦[1,2] 毛继康 

机构地区：[1]解放军第二五二医院心内科 [2]解放军总医院老年心血管病研究所

出　　处：《中西医结合实用临床急救》1998年第12期541-543,共3页

摘　　要：目的：观察地尔硫艹卓对心绞痛患者血清内源性洋地黄物质（ＥＤＬＳ）浓度的影响。方法：５７例心绞痛患者（稳定型心绞痛３１例，不稳定型心绞痛２６例），予地尔硫艹卓３０ｍｇ口服，每日３次，连服２周。治疗前后应用放射免疫法测定血清ＥＤＬＳ浓度。结果：稳定型及不稳定型心绞痛患者血清ＥＤＬＳ浓度分别为（３２３．５±１００．２）ｎｇ／Ｌ和（４１１．５±１１６．９）ｎｇ／Ｌ，均较正常对照组〔（１９８．５±１１２．４）ｎｇ／Ｌ〕明显增高（Ｐ＜０．０５和Ｐ＜０．０１），其中不稳定型心绞痛ＥＤＬＳ浓度增高尤为明显，与稳定型心绞痛组比较有显著性差异（Ｐ＜０．０５）。地尔硫艹卓在明显改善心绞痛症状的同时，能够使ＥＤＬＳ浓度降低，稳定型及不稳定型心绞痛患者治疗后ＥＤＬＳ浓度分别为（２４５．３±９８．６）ｎｇ／Ｌ和（３１８．７±１０９．４）ｎｇ／Ｌ，均较治疗前显著降低（Ｐ均＜０．０５）。结论：ＥＤＬＳ在冠心病心绞痛发病机制中起重要作用。Objective:To observe the influence of diltiazem on serum endogenous digitalislike substance (EDLS) in patients with angina pectoris.Methods:Fiftyseven cases of angina pectoris including stable form (31 cases) and unstable form (26 cases),they were treated with oral diltiazem 30 mg ,3 times daily for 2 weeks.Moreover,to detect the serum EDLS concentration preand post medication with radioimmunoassay.Results:The serum EDLS concentration were (323 5±100 2) ng/L and (411 5±116 9)ng/L respectively,preand post therapy in angina pectoris patients,it were raised obviously than normal control group (198 5±112 4)ng/L, P <0 05 and P <0 01 ,particulaly in unstable angina pectoris patients who were obvious difference from stable form ( P <0 05).Diltiazem could be decreased the EDLS concentration at the same time of improving angina pectoris symptom.The EDLS concentrations in patients with stable and unstable angina pectoris were (245 3±98 6)ng/L and (318 7±109 4) ng/L respectively following therapy,they were decreased markedly as compared to before therapy (all P <0 05).Conclusions:EDLS has an important role in pathogenesis of angina pectoris and diltiazem may decrease EDLS concentration via reduce Ca 2+ influx.

关 键 词：心绞痛 内源性 洋地黄 地尔硫Zuo 

分 类 号：R541.405[医药卫生—心血管疾病] R972[医药卫生—内科学]