医用几丁糖与透明质酸钠预防腹部术后肠粘连的对比研究  

A Clinical Comparison on Prevention of Postoperative Ankylenteron by Chitosan or Sodiumhyaluronate

作　　者：郭迅[1] 裴明祥[1] 邱福轩[1] 田银海[1] 

机构地区：[1]河南省焦作煤业集团中央医院,454000

出　　处：《中国医药指南》2010年第9期26-27,共2页Guide of China Medicine

摘　　要：目的对比研究几丁糖与透明质酸钠预防腹部术后肠粘连的临床效果。方法根据患者选择抗粘连药物的不同,将患者随机分为几丁糖组和透明质酸钠组,术毕将几丁糖或透明质酸均匀涂抹于手术创面、肠管受损的浆膜面和切口周围腹壁,观察术后肠管通气时间及术后1年腹痛、腹胀、肛门停止排便排气、腹部压痛、气过水音、液气平面等反映胃肠功能的相关指标。结果两组患者一般情况及手术方式分布差异没有统计学意义(P>0.05)。虽然两组患者在腹胀及腹部压痛量指标差异没有统计学意义(P>0.05),但是两组患者术后肠管通气时间、腹痛、呕吐、肛门停止排便排气、气过水音、液气平面等指标差异有统计学意义(P<0.05)。结论几丁糖较透明质酸钠预防腹部手术后肠粘连更有优势。Objective To compare the effect of chitosan or sodiumhyaluronate on the prevention of postoperative ankylenteron. Method Patients undergoing laparotomy were randomly divided into chitosan group and sodiumhyaluronate group. Chitosan or sodiumhyaluronate was smeared in wound surface and around abdominal cavity for preventing postoperative ankylenteron. Passage of gas by anus and bellyache, abdominal distention, abdominal tenderness and liquid-gas plane etc after operation an year were compared. Results There were no statistical difference in general patient state and surgical modality（P〉0.05）.Although there were no statistical difference in abdominal distention and abdominal tenderness, there were significantly statistical difference in passage of gas by anus, bellyache, liquid-gas plane etc（P〈0.05）. Conclusion In contrast to sodiumhyaluronate, chitosan has more predominant on the prevention of postoperative ankylenteron.

关 键 词：几丁糖 透明质酸钠 肠粘连 预防 

分 类 号：R656[医药卫生—外科学]